{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:11:49Z","timestamp":1767093109719,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin hyperpigmentation is the darkening of skin due to the increased production of melanin in the body.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy and safety of a botanical\u2010based Rosa E pigmentation serum in healthy fair skin female volunteers with wrinkles, skin tone, and pigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010arm, open label study conducted in healthy Indian females; 18 subjects aged 30\u201055, having fair Caucasian\u2010like skin with at least 2 dark skin pigments with facial wrinkles diagnosed by dermatologist were selected. Rosa E pigmentation serum was applied twice a day for 84 days. Effect was evaluated by (i) instrumental technique (spectrophotometer<jats:sup>\u00ae<\/jats:sup> 2600D), (ii) clinically by dermatologist regarding product efficacy (skin tone, antiwrinkle, pigmentation), and (iii) volunteers self\u2010evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>L<\/jats:italic>* value of spectrophotometer reading represents lightness in the skin pigment. Reduction in the pigment was reported from day 14, with significant reductions observed till day 84 compared with baseline. Significant (<jats:italic>P<\/jats:italic> &lt; .0001) skin pigmentation lightening was seen on day 14 (1.11) vastly improving on day 84 (1.94) based on photographic assessments. The significant reduction in skin pigment was 76.85%, Felix von Luschan skin color score was 30.24% (<jats:italic>P<\/jats:italic> &lt; .0001) with a 7.38\u2010fold reduction in skin tone and 57% reduction in facial wrinkles at day 84 from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rosa E pigmentation serum was found safe and effective in significant reduction in skin pigments, improvement of skin tone, and antiwrinkle properties instrumentally, clinically, and self\u2010evaluation by volunteers. In these evaluations, best results were seen the longer the Rosa E was used.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12435","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:26:16Z","timestamp":1511976376000},"page":"830-839","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and safety of topical depigmenting agent in healthy human fair skin female volunteers: A single\u2010arm study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-9030","authenticated-orcid":false,"given":"Saurabh","family":"Shah","sequence":"first","affiliation":[{"name":"Saurabh Shah Advanced Skin &amp; Hair Care Clinic Hinduja College Behind Saifee Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon\u2010Keong","family":"Chew","sequence":"additional","affiliation":[{"name":"Maxwell Pharma Sdn Bhd Zenith Corporate Park Petaling Jaya Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"51","article-title":"An epidemiological survey of the use of cosmetic skin lightening cosmetics among traders in Lagos, Nigeria","volume":"21","author":"Adebajo SB","year":"2002","journal-title":"West Afr J Med"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.3390\/ijms10094066"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1080\/09546630410033790"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.4103\/0378-6323.58671"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.5114\/pdia.2013.37032"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1007\/s11746-006-5013-2"},{"key":"e_1_2_8_8_1","first-page":"283","article-title":"Contribution to the identification of Rosa aff. rubiginosa L. oil rose active principles","volume":"56","author":"Pareja B","year":"1990","journal-title":"An Real Acad Farm"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.4103\/0974-2077.110089"},{"unstructured":"SpiersSM CleavesFT.Topical treatment of the skin with a grape seed oil composition. Google Patents.https:\/\/www.google.com\/patents\/US5916573(1999).","key":"e_1_2_8_10_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1016\/j.sder.2009.04.001"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.4103\/0019-5154.190103"},{"key":"e_1_2_8_13_1","first-page":"634","article-title":"Lightening and illuminating skin with acetylated hydroxystilbenes from Rheum rhaponticum","volume":"126","author":"Dell'Acqua G","year":"2011","journal-title":"Cosmetics & Toiletries Magazine"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.3892\/etm.2014.2118"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.4103\/0019-5154.135476"},{"key":"e_1_2_8_16_1","first-page":"350","article-title":"An open label, non\u2010comparative, non\u2010randomized, pilot study to see the efficacy and safety of wrinkle cream in treatment of facial skin wrinkles","volume":"2","author":"Madan A","year":"2014","journal-title":"Int J Adv Res"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12435","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T21:26:36Z","timestamp":1694899596000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/jocd.12435"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12435","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2017,11,28]]}}}