{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:16:13Z","timestamp":1774617373968,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ethanolic extract from blueberry (<jats:italic>Vaccinium myrtillus<\/jats:italic>) is rich in anthocyanins and thus exhibits antioxidant activity. On the other hand, ultradeformable liposomes are capable of penetrating to the impermeable barrier of skin. Nanoberries are ultradeformable liposomes carrying blueberry extract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this study, their capacity to penetrate the<jats:italic>stratum corneum<\/jats:italic>and photodamage prevention were tested, with the aim of developing a topical formulation for skin protection from environmental damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nanoberries were prepared by lipid film resuspension with ethanolic extract from blueberry, followed by sonication and incorporation to a gel. Size, zeta potential, deformability, rheology, and viscoelasticity were determined. Toxicity was assessed in vivo in zebrafish model, while in vitro cytotoxicity assay was performed on HaCaT and<jats:styled-content style=\"fixed-case\">HEK<\/jats:styled-content>\u2010293T cell lines. Skin penetration was evaluated with the Saarbr\u00fccken penetration model followed by tape stripping, cryosection, or optical sectioning.<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010damage protection and photoprotection were determined by ad hoc methods with<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">UVC<\/jats:styled-content>radiation on HaCaT cells. Wound assay was performed on HaCaT cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nanoberries of about 100 nm, with differential elastic properties, did penetrate the<jats:italic>stratum corneum<\/jats:italic>, with low toxicity. When HaCaT cells were exposed to<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>radiation in the presence of nanoberries, their viability was maintained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nanoberries could be effective to protect the skin from sun photodamage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12436","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T04:02:42Z","timestamp":1507089762000},"page":"889-899","source":"Crossref","is-referenced-by-count":24,"title":["Skin penetration and<scp>UV<\/scp>\u2010damage prevention by nanoberries"],"prefix":"10.1111","volume":"17","author":[{"given":"Paula","family":"Bucci","sequence":"first","affiliation":[{"name":"Laboratory of Biomembranes \u2010 GBEyB (IMBICE, CCT\u2010La Plata, CONICET) Departamento de Ciencia y Tecnolog\u00eda National University of Quilmes Bernal Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jimena","family":"Prieto","sequence":"additional","affiliation":[{"name":"Laboratory of Biomembranes \u2010 GBEyB (IMBICE, CCT\u2010La Plata, CONICET) Departamento de Ciencia y Tecnolog\u00eda National University of Quilmes Bernal Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Milla","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology National University of R\u00edo Cuarto R\u00edo Cuarto C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Natalia","family":"Calienni","sequence":"additional","affiliation":[{"name":"Laboratory of Biomembranes \u2010 GBEyB (IMBICE, CCT\u2010La Plata, CONICET) Departamento de Ciencia y Tecnolog\u00eda National University of Quilmes Bernal Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Martinez","sequence":"additional","affiliation":[{"name":"Laboratory of Biomembranes \u2010 GBEyB (IMBICE, CCT\u2010La Plata, CONICET) Departamento de Ciencia y Tecnolog\u00eda National University of Quilmes Bernal Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Rivarola","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology National University of R\u00edo Cuarto R\u00edo Cuarto C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Alonso","sequence":"additional","affiliation":[{"name":"Laboratory of Biomembranes \u2010 GBEyB (IMBICE, CCT\u2010La Plata, CONICET) Departamento de Ciencia y Tecnolog\u00eda National University of Quilmes Bernal Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9177-0240","authenticated-orcid":false,"given":"Jorge","family":"Montanari","sequence":"additional","affiliation":[{"name":"Laboratory of Biomembranes \u2010 GBEyB (IMBICE, CCT\u2010La Plata, CONICET) Departamento de Ciencia y Tecnolog\u00eda National University of Quilmes Bernal Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-461011-8.50007-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.1511"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf071988k"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.1.207"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.230S"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.019"},{"key":"e_1_2_7_8_1","first-page":"59","volume-title":"An R Acad Nac Farmac","author":"Angosto MC","year":"2010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12234"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15218"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000440698"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2016.09.064"},{"key":"e_1_2_7_13_1","first-page":"469","article-title":"Nanoberries for topical delivery of antioxidants","volume":"64","author":"Montanari J","year":"2012","journal-title":"J Cosmet Sci"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(92)90154-E"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.08.014"},{"key":"e_1_2_7_16_1","first-page":"370","article-title":"In vitro activity against Leishmania and human skin permeation of miltefosine ultradeformable liposomes","volume":"66","author":"Hern\u00e1ndez I","year":"2014","journal-title":"Rev Cubana Med Trop"},{"key":"e_1_2_7_17_1","first-page":"549","article-title":"Advanced carrier systems in cosmetics and cosmeceuticals: a review","volume":"62","author":"Li D","year":"2011","journal-title":"J Cosmet Sci"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270105"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0703304"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90172-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/127495"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.01.012"},{"key":"e_1_2_7_23_1","first-page":"121","article-title":"G4. 5 pamam dendrimer\u2010risperidone: biodistribution and behavioral changes in in vivo model","volume":"4","author":"Prieto MJ","year":"2013","journal-title":"J Nanomedicine Biotherapeutic Discov"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24636"},{"key":"e_1_2_7_25_1","first-page":"b24","article-title":"An ex\u2010vivo model for the study of drug penetration into human skin","volume":"13","author":"Schaefer U","year":"1996","journal-title":"Pharm Res"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.30"},{"key":"e_1_2_7_28_1","volume-title":"Anthocyanins in Fruits, Vegetables and Grains","author":"B\u00f6hm H","year":"1993"},{"key":"e_1_2_7_29_1","volume-title":"Rheological Methods in Food Process Engineering","author":"Steffe JF","year":"1996"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2015.08.038"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.07.015"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1122\/1.3538092"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.18233\/APM36No4pp364-368"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2009.8"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209384"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008200802585622"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1462"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018064"},{"key":"e_1_2_7_39_1","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.3760\/cma.j.issn.0366-6999.20122728","article-title":"Effect of pomegranate peel polyphenol gel on cutaneous wound healing in alloxan\u2010induced diabetic rats","volume":"126","author":"Yan H","year":"2012","journal-title":"Chin Med J"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T13:30:38Z","timestamp":1719495038000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,3]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/jocd.12436"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12436","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,3]]}}}