{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T01:58:06Z","timestamp":1782611886034,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several treatment modalities had been used for the treatment of vitiligo, but the optimal treatment has not yet been identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the efficacy of microneedling with 5\u2010flurouracil vs its efficacy with tacrolimus in the treatment of vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Twenty\u2010five patients with vitiligo were subjected to microneedling of 2 patches of vitiligo with dermapen, then application of 5\u2010fluorouracil to 1 patch and tacrolimus on the other patch. This procedure was repeated every 2\u00a0weeks for every patient for maximum 6\u00a0months (12 sessions). The patients were followed up for 3\u00a0months after the last session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall repigmentation was significantly higher in 5\u2010fluorouracil\u2010treated patches compared with tacrolimus. Excellent improvement occurred in 48% of 5\u2010 flurouracil\u2010treated patches while only in 16% of tacrolimus\u2010treated patches. In the acral parts, 40% of the patches treated with 5\u2010fluorouracil achieved excellent improvement (repigmentation &gt;75%), while no patch in the acral parts achieved excellent improvement with tacrolimus. However, there was significant difference between the 2 drugs,regarding inflammation, ulceration, and hyperpigmentation which occurred with 5\u2010fluorouracil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Microneedling combined with 5\u2010fluorouracil or tacrolimus is safe and effective treatment of vitiligo. However, 5\u2010fluorouracil achieved a greater percentage of repigmentation than tacrolimus particularly in the acral parts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12440","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T10:23:02Z","timestamp":1521109382000},"page":"744-751","source":"Crossref","is-referenced-by-count":61,"title":["Comparison between the efficacy of microneedling combined with 5\u2010fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-2843","authenticated-orcid":false,"given":"Mary","family":"Mina","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Dermatology &amp; Venereology Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Elgarhy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of pathology Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Al\u2010saeid","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Dermatology &amp; Venereology Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Dermatology &amp; Venereology Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/11630540-000000000-00000"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.16778"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02127.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.10.023"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03226.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2008.00385.x"},{"key":"e_1_2_6_8_1","first-page":"49","article-title":"Possible mechanisms by which topical 5\u2010Fluorouracil and dermabrasion could induce pigment spread in vitiligo skin: an experimental study","volume":"8","author":"Gauthier Y","year":"2013","journal-title":"ISRN Dermatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2002.01541.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-013-2594-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01632.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.112357"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12647"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(03)00045-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02101.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30058.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00926.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2012.11.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-2-12"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2011.579084"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12742"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2014.1003241"},{"key":"e_1_2_6_23_1","first-page":"149","article-title":"Needling: an adjunct to narrowband ultraviolet B therapy in localized fixed vitiligo","volume":"18","author":"Ahmed T","year":"2008","journal-title":"J Pak Assoc Dermatol"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T21:25:26Z","timestamp":1694899526000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,12]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/jocd.12440"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12440","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,12]]}}}