{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:11:14Z","timestamp":1785305474167,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,22]],"date-time":"2017-10-22T00:00:00Z","timestamp":1508630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>Treatment of mixed melasma remains challenging. Promising results have been achieved with low\u2010fluence 1064\u2010nm Q\u2010switched Nd\u2010<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser; however, multiple sessions are necessary with occurrence of complications especially in dark skin types. So, combination methods may be recommended.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare efficacy of Q\u2010switched Nd\u2010<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser alone or with modified Jessner's peel in mixed melasma in dark skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Nineteen patients with mixed melasma received 6 sessions of laser on left side of face and alternating laser and modified Jessner on right side. Evaluation was carried out clinically through modified melasma area and severity index at 1\u00a0month after last session. Using histopathological, immunohistochemical, and computerized morphometric analysis, objective evaluation of melanin particle surface area and <jats:styled-content style=\"fixed-case\">MART<\/jats:styled-content>\u20101\u2010positive cells was performed for pre\u2010 and post\u2010treated skin biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was significant clinical improvement on both sides of face (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), without significant difference (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). At the sixth laser session on left side of face, ill\u2010defined mottled hypopigmentation was observed in 21.05% of patients. Histopathologically, melanin particle surface area and number of <jats:styled-content style=\"fixed-case\">MART<\/jats:styled-content>\u20101\u2010positive cells (total, epidermal, and dermal) were significantly decreased after two treatment modalities (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), without significant difference in their reduction percentage between both sides of face (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010fluence Q\u2010switched Nd\u2010<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser alone and with modified Jessner's peel are equally effective regimens for mixed melasma clinically, histopathologically, and immunohistochemically. However, combined method is preferred, especially in dark skin, for obtaining better cosmetic result with fewer side effects of multiple laser sessions and decreasing cost rate of laser.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12444","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T04:22:39Z","timestamp":1508732559000},"page":"319-327","source":"Crossref","is-referenced-by-count":30,"title":["Q\u2010switched Nd: <scp>YAG<\/scp> laser alone or with modified Jessner chemical peeling for treatment of mixed melasma in dark skin types: A comparative clinical, histopathological, and immunohistochemical study"],"prefix":"10.1111","volume":"17","author":[{"given":"Fatma","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Dermatology STDs and Andrology Faculty of Medicine Minia University Al\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0444-2311","authenticated-orcid":false,"given":"Noha H","family":"Moftah","sequence":"additional","affiliation":[{"name":"Department of Dermatology STDs and Andrology Faculty of Medicine Minia University Al\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Abdel\u2010Azim","sequence":"additional","affiliation":[{"name":"Department of Dermatology STDs and Andrology Faculty of Medicine Minia University Al\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa G","family":"Gharieb","sequence":"additional","affiliation":[{"name":"Dermatology and leprosy Hospital Al\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690240119022"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.848261"},{"key":"e_1_2_5_4_1","first-page":"21","article-title":"Current peeling methods","volume":"29","author":"Wiest L","year":"2003","journal-title":"Hautarzt"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.104912"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.EWX.0000450911.98980.82"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.48985"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20956"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01383.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2012.04473.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04150.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.104915"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.EWX.0000453689.94338.3b"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.12-OR-03"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000065"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmicro\/dfq068"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02001.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277339"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.03070.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-0963.2001.04556.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181ef2d45"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12290550"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(96)00211-6"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290703.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.3.340"},{"key":"e_1_2_5_26_1","first-page":"9","article-title":"High fluence, high beam quality Q\u2010 switched Nd: YAG laser with optoflex delivery system for treating benign pigmented lesions and tattoos","volume":"2010","author":"Cencic B","year":"2010","journal-title":"J Laser Health Academy"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:31:29Z","timestamp":1695490289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,22]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/jocd.12444"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12444","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,22]]}}}