{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:40:37Z","timestamp":1790458837886,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Superficial chemical peels are frequently used in acne vulgaris treatment. Although glycolic acid (GA<\/jats:styled-content>) has been widely used in clinical practice, its pH<\/jats:styled-content> ranges from 0.08\u20102.75 and thus should be neutralized after application to avoid burns.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate treatment efficacy and safety of chemical peeling using buffered 50% GA<\/jats:styled-content> (pH<\/jats:styled-content> 3.0)\u00a0+\u00a00.5% salicylic acid (SA<\/jats:styled-content>) solution that does not need to be neutralized in the treatment of acne vulgaris compared to the conventional peeling using Jessner's solution.<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed a prospective, randomized, evaluator\u2010blind, split\u2010face clinical trial. Twenty patients were randomized by assigning one side of each patient's face to receive a 50% GA<\/jats:styled-content> (pH<\/jats:styled-content> 3.0)\u00a0+\u00a00.5% SA<\/jats:styled-content> peel (GA<\/jats:styled-content> side) and the other side to receive the Jessner's solution (Jessner's solution side). All patients underwent 2 sessions of treatment spaced 2\u00a0weeks apart. Lesion count, acne severity, subjective efficacy assessment, and side effects were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>The total lesion count was significantly reduced for the GA<\/jats:styled-content> and Jessner's solution sides (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001). However, there was no significant difference in the total lesion count, acne severity, or subjective efficacy assessment between the 2 sides (P\u00a0<\/jats:italic>>\u00a0<\/jats:italic>.05). The GA<\/jats:styled-content> side had fewer side effects than the Jessner's solution side.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The results of this study suggest that chemical peeling using the 50% GA<\/jats:styled-content> (pH<\/jats:styled-content> 3.0)\u00a0+\u00a00.5% SA<\/jats:styled-content> solution can be as effective and convenient as the conventional peeling using Jessner's solution in the treatment of acne vulgaris and may show fewer adverse events than the conventional peeling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12445","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T04:24:56Z","timestamp":1511324696000},"page":"797-801","source":"Crossref","is-referenced-by-count":13,"title":["Comparative study of buffered 50% glycolic acid (pH<\/scp> 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9948-2318","authenticated-orcid":false,"given":"Jeong","family":"In Jae","sequence":"first","affiliation":[{"name":"Department of Dermatology CHA Bundang Medical Center CHA University Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Dong Ju","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHA Bundang Medical Center CHA University Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Dong Hyun","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHA Bundang Medical Center CHA University Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Soo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHA Bundang Medical Center CHA University Seongnam 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