{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:41:53Z","timestamp":1778730113496,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hair transplant surgery using follicular unit extraction technique (<jats:styled-content style=\"fixed-case\">FUE<\/jats:styled-content>) is a common surgical procedure for the treatment of severe hair loss. Blood\u2010derived autologous growth factors have also proved to promote hair regeneration in patients with different types of alopecia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>) technology as an adjuvant therapy for<jats:styled-content style=\"fixed-case\">FUE<\/jats:styled-content>surgery in hair loss affected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The biologic potential of<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>was firstly in\u00a0vitro evaluated over follicular germinal matrix and dermal papilla cells. Afterward, fifteen patients were subjected to routine<jats:styled-content style=\"fixed-case\">FUE<\/jats:styled-content>procedure while 15 patients underwent<jats:styled-content style=\"fixed-case\">FUE<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>therapy.<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>group included intradermal injections of growth factors and follicular transfer unit (<jats:styled-content style=\"fixed-case\">FTU<\/jats:styled-content>) preservation in an autologous fibrin clot. Postsurgical patient satisfaction and clinical improvement were evaluated, and<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>or saline\u2010preserved hair grafts were histomorphometrically analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follicular cell proliferation and migration was induced after autologous growth factors treatment.<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>\u2010preserved<jats:styled-content style=\"fixed-case\">FTU<\/jats:styled-content>s presented higher bioactivity signals and improved integrity of perifollicular structures and extracellular matrix proteins such as collagen and elastic fibers.<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>not only reduced the postsurgical crust healing and hair fixation period, but also decreased the inflammatory pain and itching sensation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This preliminary data demonstrate that<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>is able to minimize the postsurgical follicle loss and potentiate the performance of grafted hairs. The fibrin clot not only acts as a protective barrier against environmental factors, but also provides a biologically active scaffold that induces resident cell proliferation and maintains an optimal integrity of the grafted hair.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12446","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T04:14:37Z","timestamp":1509077677000},"page":"862-873","source":"Crossref","is-referenced-by-count":18,"title":["The effect of plasma rich in growth factors combined with follicular unit extraction surgery for the treatment of hair loss: A pilot study"],"prefix":"10.1111","volume":"17","author":[{"given":"Roge M.","family":"Navarro","sequence":"first","affiliation":[{"name":"Centro Dermatol\u00f3gico\u2010Est\u00e9tico de Alicante Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ander","family":"Pino","sequence":"additional","affiliation":[{"name":"BTI Biotechnology Institute Vitoria 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