{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:24:20Z","timestamp":1769423060828,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,19]],"date-time":"2017-11-19T00:00:00Z","timestamp":1511049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Deputy of Research, Alborz University of Medical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>Natural ingredients have been always an interesting approach to prolong youthful appearance of skin. One of the natural compounds is Kombucha tea (KT), which has been mainly used as an energy drink in Asian countries for a long time. Previous reports indicated that it has pharmaceutical and favorable wound repairing effects. The beneficial properties of KT are thought to be mainly due to the presence of fermentation products such as flavonoids and other polyphenols with inhibition of hydrolytic and oxidative enzymes and anti\u2010inflammatory effects. These properties prompted us to study the anti\u2010aging potential of KT and investigate its effective fraction in aged mice,<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Kombucha tea was fractionated into chloroform, butanol, and ethyl acetate, and flavonoid content was determined. Young and old mice were used as control. KT ethyl acetate fraction (<jats:styled-content style=\"fixed-case\">KEA<\/jats:styled-content>f), which had the highest flavonoid content, was intradermally administered to old mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Administration of<jats:styled-content style=\"fixed-case\">KEA<\/jats:styled-content>f significantly increased the collagen content,<jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content><jats:sup>+<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">NADH<\/jats:styled-content>level, and concomitantly improved skin connective tissue abnormalities in the aged skin. No sensitivity or irritation was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This finding suggested that<jats:styled-content style=\"fixed-case\">KEA<\/jats:styled-content>f can be a suitable candidate as a cosmetic product to improve aging\u2010related skin abnormalities and regeneration of aged skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12453","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T04:06:42Z","timestamp":1511150802000},"page":"1216-1224","source":"Crossref","is-referenced-by-count":19,"title":["Cosmeceutical effect of ethyl acetate fraction of Kombucha tea by intradermal administration in the skin of aged mice"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-1738","authenticated-orcid":false,"given":"Nafiseh","family":"Pakravan","sequence":"first","affiliation":[{"name":"Division of Immunology Medical School Alborz University of Medical Sciences Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaheh","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology Medical School Alborz University of Medical Sciences Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed\u2010Ali","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical School Alborz University of Medical Sciences Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamal","family":"Kamali","sequence":"additional","affiliation":[{"name":"Department of Operating Room Nursing Paramedical School Alborz University of Medical Sciences Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Hajiaghayi","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Center Institute of Medicinal Plant ACECR Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitra","family":"Rahimzadeh","sequence":"additional","affiliation":[{"name":"Health, Safety, and Environment Research Center Alborz University of Medical Sciences Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vajiheh","family":"Mahmoodi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Faculty of Agriculture Islamic Azad University Shahrekord Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(89)90372-8"},{"key":"e_1_2_7_3_1","first-page":"123","article-title":"Cutaneous aging: chronologic versus photoaging","volume":"1","author":"Lavker R","year":"1995","journal-title":"Photodam"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70465-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00902.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1437"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-32953-6_2"},{"key":"e_1_2_7_8_1","first-page":"2524","article-title":"The content and ratio of type I and III collagen in skin differ with age and injury","volume":"10","author":"Cheng W","year":"2011","journal-title":"Afr J Biotech"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051302"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.2187"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2011.10.003"},{"key":"e_1_2_7_12_1","unstructured":"PerriconeNV.Treatment of skin damage using polyenylphosphatidylcholine. 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