{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:23:05Z","timestamp":1791451385406,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,10]],"date-time":"2017-12-10T00:00:00Z","timestamp":1512864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Minimally invasive procedures provide effective, safe, relatively long\u2010lasting, and natural results without large damage to the skin. A combination treatment is considered an approach that includes at least 2 different and unrelated modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to evaluate the use and effectiveness of some combined minimally invasive procedures for management of acne scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/methods<\/jats:title><jats:p>Twenty\u2010four volunteers with postacne atrophic scars were randomly divided into 3 equal groups according to performed procedure on each side of the face (microneedling by dermaroller alone or combined with platelet\u2010rich plasma [<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>] or trichloroacetic acid [<jats:styled-content style=\"fixed-case\">TCA<\/jats:styled-content>] 15% peeling) and received 6 bi\u2010weekly sessions of treatment. Photography and punch biopsies were taken before and after 3 months of treatment for clinical, histological, and histometrical evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Combined treatment of dermaroller and <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> or dermaroller and <jats:styled-content style=\"fixed-case\">TCA<\/jats:styled-content> 15% showed significant improvement when compared with dermaroller alone (<jats:italic>P<\/jats:italic> = .015 and .011 respectively). Epidermal thickness showed statistically significant increase in studied groups, mainly after dermaroller and <jats:styled-content style=\"fixed-case\">TCA<\/jats:styled-content> 15%. Moreover, the 3 studied groups showed more organized collagen bundles and newly formed collagen formation and markedly decreased abnormal elastic fibers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on the clinical, histometrical, and histochemical assessment, inspite that most volunteers showed significant improvement after treatment, however, the combined use of dermaroller and <jats:styled-content style=\"fixed-case\">TCA<\/jats:styled-content> 15% was more effective in postacne atrophic scars than the use of dermaroller and <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> or dermaroller only.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12459","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T03:56:54Z","timestamp":1512964614000},"page":"73-83","source":"Crossref","is-referenced-by-count":71,"title":["Microneedling combined with platelet\u2010rich plasma or trichloroacetic acid peeling for management of acne scarring: A split\u2010face clinical and histologic comparison"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-2442","authenticated-orcid":false,"given":"Moetaz","family":"El\u2010Domyati","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Minia University Al\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam","family":"Abdel\u2010Wahab","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Minia University Al\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliaa","family":"Hossam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Minia University Al\u2010Minya 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