{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T01:23:42Z","timestamp":1772673822063,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T00:00:00Z","timestamp":1520121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Department of Plastic and cosmetic surgery Affricated hospitical of Qingdao University as well as Qingdao Experimental Animal Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the influence of hyperbaric oxygen on scar formation in rabbit ears.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 20 New Zealand rabbits were selected to establish the hypertrophic scar model on the ears. The rabbits were randomly divided into control group and experimental group (7d, 14d, 21d, and 28d group according to different <jats:styled-content style=\"fixed-case\">HBO<\/jats:styled-content> treatment days),each experimental group received hyperbaric oxygen treatment after the operation at the same time everyday for 1\u00a0hour. After the day 29, the scars were collected. Histomorphological change in scars was observed by hematoxylin\u2010eosin staining, Masson staining, and transmission electrical microscope. The expression of bax, bcl\u20102, and the cell apoptosis rate was detected by immunohistochemical method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(i) Both number of fibroblast and amount of collagen fibrils in experimental group were significantly reduced compared with those in control group. In Masson staining, arrangement of collagen fibrils in experimental group was much more irregular and coarse than control groups. (ii) <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> value can be found much smaller in the experimental groups than the control (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Among the four experimental groups, there is significant difference among 7d, 14d, and 21d groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), while there is no difference between 21d and 28d groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). (iii) Expression of Bax could be detected up\u2010regulated in experimental group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). While the expression of Bcl\u20102 is detected significantly down\u2010regulated in experimental group than that in control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Compared with the 7d group, the expression of Bax and Bcl\u20102 has significant difference in 14d group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), and the expression of this two factors in 21d group has significant difference comparing with 14d group(<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05),but there is no significant difference between 28d group and 21d group(<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). (iv) Significant difference of cell apoptosis rate can be detected between the experimental groups and the control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Among the four experimental groups, there is significant difference among 7d, 14d, and 21d groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), while there is no difference between 21d and 28d groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The hyperbaric oxygen can up\u2010regulate bax\/bcl\u20102 value, increase the cell apoptosis rate, and inhibit the early hypertrophic scar in rabbit ears.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12468","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T04:14:35Z","timestamp":1520223275000},"page":"1240-1249","source":"Crossref","is-referenced-by-count":7,"title":["Effect of hyperbaric oxygen on the process of hypertrophic scar formation in rabbit ears"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0816-7035","authenticated-orcid":false,"given":"Jizhen","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Plastic and cosmetic surgery Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Qingdao Health School Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin'e","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Plastic and cosmetic surgery Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enhao","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Plastic and cosmetic surgery Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic and cosmetic surgery Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1001\/archderm.1975.01630130062006","article-title":"Alterations of hypertrophic scars induced by mechanical pressure","volume":"111","author":"Kischer CW","year":"1975","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12474"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12343"},{"key":"e_1_2_6_5_1","first-page":"299","article-title":"The influence of Matrine on apoptosis of fibroblasts and the expression of apoptotic modulation related protein in hypertrophic 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