{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:28:10Z","timestamp":1740126490908,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Palmar hyperhidrosis is of great concern to patients because of its physical, occupational, and psychological impact on quality of life. Topical clove oil has been used in many conditions due to its major component Eugenol that<jats:italic>exerts blocking<\/jats:italic>effect on nerve transmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the work<\/jats:title><jats:p>To assess the efficacy of topical liposome incorporated clove oil in decreasing the rate of sweating among patients with idiopathic palmar hyperhidrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and method<\/jats:title><jats:p>Forty patients with palmar hyperhidrosis were treated with clove oil 45% in liposome and another twenty patients were treated as a control group with 0.9% saline solution and evaluation was carried out before and after treatment through gravimetry testing and hyperhidrosis disease severity scale (<jats:styled-content style=\"fixed-case\">HDSS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The gravimetry testing among clove oil\u2010treated group showed that the mean sweating rate before treatment was 80.5\u00a0\u00b1\u00a041.85 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>)\u00a0mg\/min which decreased significantly after treatment to 52.98\u00a0\u00b1\u00a037.94(<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>)\u00a0mg\/min (<jats:italic>P<\/jats:italic>value\u00a0&lt;\u00a0.001). On the other hand, the placebo\u2010treated group,(control) the mean sweating rate before treatment was 77.40\u00a0\u00b1\u00a029.29(<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) which did not show significant improvement after placebo application 77.35\u00a0\u00b1\u00a028.29(<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>;<jats:italic>P<\/jats:italic>value\u00a0=\u00a0.957).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The topical application of 45% clove oil in liposome twice daily for 2\u00a0weeks showing promising result evidenced by declining in the rate of palmar sweating among patients with idiopathic palmar hyperhidrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12471","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T04:12:57Z","timestamp":1514520777000},"page":"1084-1089","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of topical liposome incorporated clove oil in the treatment of idiopathic palmar hyperhidrosis: Single\u2010blinded placebo\u2010controlled study"],"prefix":"10.1111","volume":"17","author":[{"given":"Ibrahim M","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology Faculty of Medicine Al\u2010Azhar University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5011-2014","authenticated-orcid":false,"given":"Ibrahim M","family":"Abdel Kareem","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Faculty of Medicine Al\u2010Azhar University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A","family":"Alghobashy","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Faculty of Medicine Al\u2010Azhar University Cairo 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