{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:38Z","timestamp":1787015558273,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation of Hunan Administration of Traditional Chinese Medicine","award":["2016136"],"award-info":[{"award-number":["2016136"]}]},{"name":"Foundation of Hunan Health and Family Planning Commision","award":["B2015-80"],"award-info":[{"award-number":["B2015-80"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Summary<\/jats:title>\n \n Introduction<\/jats:title>\n \n The objective was to investigate the clinical effect of an adjustable pulse width Pulsed Dye Laser (\n PDL<\/jats:styled-content>\n ) vs an adjustable pulse width\n PDL<\/jats:styled-content>\n combined with fractional\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n laser in treating immature red hypertrophic scars.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Fifty\u2010six patients (56 sites)were randomly divided into a treatment group and control group. The control group was treated with the 595\u00a0nm\n PDL<\/jats:styled-content>\n at a fluence of 7\u201015J\/cm\n 2<\/jats:sup>\n and pulse widths of 1.5\u20103\u00a0ms, 7\u00a0mm spot size. The treatment group was treated with a fractional\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n laser (UltraPulse\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n : Deep\n FX<\/jats:styled-content>\n , Energy: 30~50\u00a0\n mJ<\/jats:styled-content>\n , Frequency: 300\u00a0Hz, Density 5%, Scan Shape, and Spot Size were decided by shape and area of scar) after utilizing the 595\u00a0nm adjustable pulse width\n PDL<\/jats:styled-content>\n (Fluence: 7\u201015J\/cm\n 2<\/jats:sup>\n , Pulse widths: 1.5\u20103\u00a0ms, Spot size: 7\u00a0mm).\n MEBT<\/jats:styled-content>\n \/\n MEBO<\/jats:styled-content>\n , previously described as a post\u2010treatment wound ointment, was used after laser treatment. The scars of the treatment group and the control group were evaluated for changes in pigment, height, vascularity, and pliability using the Vancouver Scar Scale (\n VSS<\/jats:styled-content>\n ) after two laser treatments.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The total\n VSS<\/jats:styled-content>\n score, as well as the score for melanin, height, vascularity, pliability in both groups, showed an obvious decrease following the treatments. There were statistically significant differences between before treatment and after treatment (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n .05); however, the total score of the\n VSS<\/jats:styled-content>\n , and score of the melanin, height, vascularity, and pliability in the control group decreased more than that of treatment group, and there was a statistically significant difference (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n .05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The 595\u00a0nm adjustable pulse width\n PDL<\/jats:styled-content>\n combined with the fractional\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n fractional laser appears to have a beneficial clinical effect on fresh red hypertrophic scars, with no severe adverse reactions seen.\n <\/jats:p>\n 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