{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T02:25:53Z","timestamp":1785637553603,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Management of alopecia areata (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>) and androgenetic alopecia (<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>) is often challenging. The use of carboxytherapy may be a novel therapeutic option for such cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical efficacy and safety of carboxytherapy in alopecia areata and androgenetic alopecia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>This study was conducted on 80 patients with alopecia divided into two groups; Group I included 40 <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients (Group <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> received carboxytherapy and Group <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content> control received placebo), and Group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> included 40 <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> patients (Group <jats:styled-content style=\"fixed-case\">IIA<\/jats:styled-content> received carboxytherapy and Group <jats:styled-content style=\"fixed-case\">IIB<\/jats:styled-content> control received placebo), and followed up monthly for 3\u00a0months. They were evaluated clinically (by assessment of Severity of Alopecia Tool (<jats:styled-content style=\"fixed-case\">SALT<\/jats:styled-content>) score in group I, and Sinclair scale and Norwood\u2010Hamilton scale in group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>), by dermoscopy and digital dermoscopy at each visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Group <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> patients showed significant clinical improvement in <jats:styled-content style=\"fixed-case\">SALT<\/jats:styled-content> score and dermoscopic improvement after carboxytherapy and at the end of follow\u2010up period with significant reduction in dystrophic hair, black dots, yellow dots, and tapered hair coinciding with significant emergence of regrowing hair. Group <jats:styled-content style=\"fixed-case\">IIA<\/jats:styled-content> patients showed significant clinical and dermoscopic improvement after carboxytherapy with significant increase in hair density measured by digital dermoscopy. However, regression of these results was observed during the follow\u2010up period but was still significantly better than before treatment. There were statistically significant improvements in clinical score, global assessments, dermoscopic, and digital dermoscopic findings in both group <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> and group <jats:styled-content style=\"fixed-case\">IIA<\/jats:styled-content> received carboxytherapy in comparison with group <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content> and group <jats:styled-content style=\"fixed-case\">IIB<\/jats:styled-content> received placebo injections, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Carboxytherapy seems to be a promising therapeutic option for patchy <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> and could be helpful as an adjuvant therapy of <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> but more than 6 sessions are required and adjuvants are recommended for maintenance of the results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12501","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T18:52:20Z","timestamp":1519239140000},"page":"1275-1285","source":"Crossref","is-referenced-by-count":32,"title":["Study of the efficacy of carboxytherapy in alopecia"],"prefix":"10.1111","volume":"17","author":[{"given":"Noha Nabil","family":"Doghaim","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania Ahmed","family":"El\u2010Tatawy","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0603-5365","authenticated-orcid":false,"given":"Yomna Mazid El\u2010Hamd","family":"Neinaa","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa Mohsen","family":"Abd El\u2010samd","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"79","article-title":"Carboxytherapy: effects on microcirculation and its use in the treatment of severe lymphedema","volume":"8","author":"Varlaro V","year":"2007","journal-title":"Acta Phlebol"},{"key":"e_1_2_8_3_1","first-page":"547","volume-title":"Aesthetic Medicine: Art and Techniques","author":"Koutn\u00e1 N","year":"2011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S102503"},{"key":"e_1_2_8_5_1","first-page":"201","article-title":"Increase in collagen turnover induced by intradermal injection of 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