{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:21:36Z","timestamp":1763202096963,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T00:00:00Z","timestamp":1520640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Narrow\u2010band ultraviolet B (NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>) is the gold standard in the treatment of vitiligo. 25\u2010hydroxyvitamin D (25\u2010OH<\/jats:styled-content>\u2010 vitamin D) might play a physiological role in photo\u2010induced melanogenesis in human skin so the association between vitamin D levels and vitiligo still needs to be investigated more thoroughly.<\/jats:p><\/jats:sec>Objective<\/jats:title>we aim to investigate the influence of cumulative doses of NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> phototherapy on vitamin D in patients with vitiligo and their correlation with NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>\u2010induced pigmentation.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eighty patients of vitiligo and twenty number of age and sex matched controls were recruited in a case\u2010control study. Patients with vitiligo were treated with NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> twice weekly for 24\u00a0weeks. 25\u2010hydroxy vitamin D levels were measured at 0, 12, and 24\u00a0weeks in the cases and at 0 only in control by enzyme\u2010linked immunosorbent assay (ELISA<\/jats:styled-content>) and Vitiligo Area Severity Index (VASI<\/jats:styled-content>) were calculated at 0 (baseline) and 24\u00a0weeks.<\/jats:p><\/jats:sec>Results<\/jats:title>The mean baseline level of 25\u2010hydroxyvitamin D (at 0\u00a0week) was significantly lower in patients than the control group. Levels of 25(OH<\/jats:styled-content>) vitamin D at 12 and 24\u00a0weeks showed significant improvement and Patients show significant reduction in VASI<\/jats:styled-content> score after 24\u00a0weeks of therapy.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Cumulative doses of NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> therapy improve low vitamin D levels in patients with vitiligo, which might have a significant role in NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>\u2010induced repigmentation and may contribute to its therapeutic efficacy but further studies with larger sample size are needed to prove the complete mechanisms of NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>\u2010induced pigmentations and vitamin D in vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12515","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T07:56:34Z","timestamp":1520668594000},"page":"911-916","source":"Crossref","is-referenced-by-count":8,"title":["Effect of narrow\u2010band ultraviolet B on the serum of 25\u2010hydroxyvitamin D in vitiligo patients"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-3302","authenticated-orcid":false,"given":"Hassan","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Qena Faculty of Medicine South Valley University Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moustafa","family":"El Taieb","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Aswan University Aswan 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