{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T15:12:35Z","timestamp":1748358755836,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the several studies suggesting the genetic basis of acne vulgaris, the exact genetic architecture of this very common condition is not yet clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the work<\/jats:title><jats:p>This study aimed to investigate the association between <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101A (\u2212889) gene polymorphism and acne vulgaris in a sample of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Method<\/jats:title><jats:p>Blood samples from 100 patients with acne vulgaris and 100 healthy age, sex, and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> matched controls were obtained. <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> samples were isolated from blood cells, and the <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content> method was used for genotyping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genotype distributions of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101A (\u2212889) polymorphism were as expected under Hardy\u2010Weinberg equilibrium. T allele was predominant in the patients, while C allele predominated in the control subjects (<jats:italic>P<\/jats:italic> value<jats:italic>\u00a0<\/jats:italic>&lt;\u00a0.001). The frequency of <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype in patients was significantly higher than in the control subjects (<jats:italic>P<\/jats:italic> value<jats:italic>\u00a0<\/jats:italic>&lt;\u00a0.001). <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> genotype was significantly more frequent in the control subjects compared to patients (<jats:italic>P<\/jats:italic> value<jats:italic>\u00a0<\/jats:italic>&lt;\u00a0.001). Among the 47 patients who reported diet as a risk factor for triggering or exacerbating their lesions, 62.5% had <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype (<jats:italic>P<\/jats:italic> value<jats:italic>\u00a0<\/jats:italic>=\u00a0.038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101A (\u2212889) gene polymorphism has a role in the pathogenesis of acne vulgaris. We suggest that the triggering or exacerbating effect of diet on acne may be related to <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101A (\u2212889) gene polymorphism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12516","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T04:16:44Z","timestamp":1519964204000},"page":"333-336","source":"Crossref","is-referenced-by-count":13,"title":["<scp>IL<\/scp>1A (\u2010889) gene polymorphism is associated with the effect of diet as a risk factor in Acne Vulgaris"],"prefix":"10.1111","volume":"18","author":[{"given":"Adel A","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Faculty of Medicine Dermatology and Andrology Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-1224","authenticated-orcid":false,"given":"Rehab M","family":"Salem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Dermatology and Andrology Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-8352","authenticated-orcid":false,"given":"Ola S","family":"El\u2010Shimi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Clinical and Chemical Pathology Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaymaa M A","family":"Baghdady","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Medical Biochemistry Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimaa","family":"Hussein","sequence":"additional","affiliation":[{"name":"Resident at Hehia Central Hospital Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/AHMT.S55832"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14385"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.11.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.528"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.51258"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(88)90019-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01530.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg232R"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380210"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.480"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04422.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1519-x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790110801"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-002-0445-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S69135"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(87)90169-8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-016-0559-z"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.2106004"}],"container-title":["Journal 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