{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:39:58Z","timestamp":1792100398221,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T00:00:00Z","timestamp":1520640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fotona Dynamis, Syneron-Candela, Sciton, Luminus, ThermiAesthics, Viveve Medical, VenusConcept and BTL Aesthetics supported research for the manuscript with a grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The use of energy\u2010based devices for the treatment of vaginal laxity<jats:bold>,<\/jats:bold> orgasmic dysfunction, and stress incontinence, such as minimally ablative fractional laser and radiofrequency, is gaining momentum. This review aims to answer clinical questions on the application of energy\u2010based devices for feminine genital rejuvenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The target group includes physicians involved in esthetic medicine and feminine genital rejuvenation. A literature review was conducted on technologies in use for feminine rejuvenation to explore their safety, efficacy, tolerability, patient satisfaction, and clinical usability. A panel of physicians with clinical experience conducting these types of treatment reviewed and discussed the results of the literature search and gave clinical evidence\u2010based recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Energy\u2010based devices may induce wound healing, stimulating new collagen, and elastin fiber formation. Radiofrequency treatment may also increase small nerve fiber density in the papillary dermis, improving nerve sensitivity, sexual function, including arousal and orgasmic dysfunction. Both minimally ablative fractional laser and radiofrequency has been shown to be effective when treating mild to moderate primary or secondary vulvovaginal laxity and associated secondary conditions. These treatments are reported to be safe, effective, and well tolerated with a rapid return to activities of daily living.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As this is an evolving medical field, clinical evidence often lacks robustness. Studies and clinical experience suggest that feminine genital rejuvenation using energy\u2010based devices seems an attractive option for patients with mild\u2010to\u2010moderate medical conditions. The treatment can be safely and effectively delivered by trained staff as part of the comprehensive care, that is, currently available to women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12524","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T07:56:40Z","timestamp":1520668600000},"page":"289-297","source":"Crossref","is-referenced-by-count":44,"title":["Review and clinical experience exploring evidence, clinical efficacy, and safety regarding nonsurgical treatment of feminine rejuvenation"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-5433","authenticated-orcid":false,"given":"Michael","family":"Gold","sequence":"first","affiliation":[{"name":"Gold Skin Care Center Nashville TN USA"},{"name":"Tennessee Clinical Research Center Nashville TN USA"},{"name":"Vanderbilt University School of Nursing Nashville TN USA"},{"name":"School of Medicine Meharry Medical College Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-4162","authenticated-orcid":false,"given":"Anneke","family":"Andriessen","sequence":"additional","affiliation":[{"name":"Radboud UMC Nijmegen The Netherlands"},{"name":"Andriessen Consultants Malden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Bader","sequence":"additional","affiliation":[{"name":"Ob&amp;Gyn, London \u2013 Dubai \u2013 Athens London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Red","family":"Alinsod","sequence":"additional","affiliation":[{"name":"Alinsod Red South Coast Urogynecology Laguna Beach CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Shane","family":"French","sequence":"additional","affiliation":[{"name":"Women's health clinic New Orleans CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Guerette","sequence":"additional","affiliation":[{"name":"Sciton Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yegor","family":"Kolodchenko","sequence":"additional","affiliation":[{"name":"Association of Laser Medicine and Cosmetology Cogerent Laser Clinics Group Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Krychman","sequence":"additional","affiliation":[{"name":"Southern California Center for Sexual Health and Survivorship Medicine Inc. 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