{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:42:26Z","timestamp":1777329746401,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis being an incurable disease, the drug dependency of the patient in most occasions causes greater health problem than psoriasis. Wherever there is flare\u2010up, immunosuppressive drugs and other antimitotic medicaments are necessary. Therefore, a safe cosmetic preparation with drug\u2010like effect on certain triggering factors of psoriasis may revolutionize the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Objectives of this study were to determine the effect of the developed formulation on several key enzymes such as lipoxygenase, collagenase, elastase, and nullifying the free radicals and glycation. All these enzymes have cascading effect in triggering the problem to inflammatory level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Biochemical and enzymatic assay was performed to determine the effect of the cosmetic formulation and its effective dosage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The findings clearly show that the formulation is effective against all the key triggering factors of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Findings undoubtedly establish the drug\u2010like effect of nondrug formulation (cosmetic formulation). The use of this formulation may minimize the relative dependency of many steroids and other medicament. As the formulation contains only proven cosmetic ingredients and herbs, long\u2010term use is unlikely to produce any side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12544","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T21:23:22Z","timestamp":1523395402000},"page":"221-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of cosmetic products for treating certain diseases\u2014Know the science"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-8718","authenticated-orcid":false,"given":"V","family":"Aruna","sequence":"first","affiliation":[{"name":"Dr. JRK's Research and Pharmaceuticals Pvt. Ltd. Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G V","family":"Amruthavalli","sequence":"additional","affiliation":[{"name":"Dr. JRK's Research and Pharmaceuticals Pvt. Ltd. Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Gayathri","sequence":"additional","affiliation":[{"name":"Dr. JRK's Research and Pharmaceuticals Pvt. Ltd. Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"407","article-title":"A role for T cell\u2010derived interleukin 22 in psoriatic skin inflammation. 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