{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:13:44Z","timestamp":1768817624613,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The immunological aspects of inflammatory acne are still incompletely understood, so this study aimed to investigate the possible role of IL\u201017 and 25 hydroxycholecalciferol (25(OH)D3) in the disease pathogenesis and progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Across\u2010sectional study has been conducted on 135 patients with active acne vulgaris of various severities and 150 matched controls. ELISA assays of serum and tissue levels of IL\u201017 and 25(OH)D3, also immunohistochemical and Western blotting demonstration of the expression patterns of lesional IL\u201017 in comparison with control group, were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean serum levels of IL\u201017 were 544.2\u00a0pg\/mL\u00a0\u00b1\u00a0477.4 SD and 42.2\u00a0pg\/mL\u00a0\u00b1\u00a08.1 SD for acne patients and controls, respectively, with significantly higher levels among the patient group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Higher IL\u201017 expression levels in active acne lesions when compared with its level in healthy skin of the controls. The mean serum levels of 25(OH)D3 among patients and controls were 33.3\u00a0ng\/mL\u00a0\u00b1\u00a09.7 SD and 51.7\u00a0ng\/mL\u00a0\u00b1\u00a02.7 SD, respectively, with significantly lower levels among the patient group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). There were significantly negative correlations between IL\u201017 and 25(OH)D3 levels (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Deficiency of vitamin D3 accompanied with higher IL\u201017 in an inverse pattern may have a possible role in active acne vulgaris.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12715","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T14:17:08Z","timestamp":1533305828000},"page":"671-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lesional and circulating levels of interleukin\u201017 and 25\u2010hydroxycholecalciferol in active acne vulgaris: Correlation to disease severity"],"prefix":"10.1111","volume":"18","author":[{"given":"Wafaa M.","family":"Abd\u2010Elmaged","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Sohag University Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essam A.","family":"Nada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Sohag University Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-9438","authenticated-orcid":false,"given":"Mohammed H.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Qena Faculty of Medicine South Valley University Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-0245","authenticated-orcid":false,"given":"Bakheet E. M.","family":"Elsadek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Pharmacy Al\u2010Azhar University, Assiut Branch Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman A.","family":"Abdelrahim","sequence":"additional","affiliation":[{"name":"Department of Histology, Qena Faculty of Medicine South Valley University Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagwa S.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine Sohag University Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Toghan","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Qena Faculty of Medicine South Valley University Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba T. I.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Sohag University Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.334"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0307-232"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3908061"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.12.010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.380"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30142"},{"key":"e_1_2_7_9_1","first-page":"106","article-title":"Cod and the consumptive: A brief history of 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