{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:25:48Z","timestamp":1790972748429,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T00:00:00Z","timestamp":1535241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"International St. Mary's Hospital, Catholic Kwandong University College of Medicine","award":["CKURF-201406830001"],"award-info":[{"award-number":["CKURF-201406830001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcutaneous pneumatic injection (TPI) is a minimally invasive, needle\u2010free modality that can be used to forcefully deliver solution into soft tissues of the face and scalp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effects of TPI of 5% isotonic and 20% hypertonic glucose solutions in in vivo human skin for face lifting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>A prospective, split\u2010face, evaluator\u2010blinded comparison study was performed on 10 Korean participants who were treated with three sessions of TPI using 5% isotonic and 20% hypertonic glucose solutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The following assessment parameters were improved after TPI therapy using 5% isotonic glucose solution in descending order of mean global aesthetic improvement scale (GAIS) score: perioral expression wrinkles, zygomatic wrinkles or mid\u2010cheek furrows, eyebrow ptosis, jowl sagging, marionette line, horizontal forehead lines, nasolabial folds, and blepharochalasis. Meanwhile, TPI therapy using 20% hypertonic glucose solution improved the following assessment parameters: zygomatic wrinkles or mid\u2010cheek furrows, perioral expression wrinkles, eyebrow ptosis, blepharochalasis, marionette line, jowl sagging, nasolabial folds, and horizontal forehead lines. Linear mixed models revealed a significant interaction between treatment groups and time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrated that TPI treatment with 20% hypertonic glucose solution elicited earlier and more pronounced therapeutic responses, compared to 5% isotonic glucose solution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12766","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T04:49:22Z","timestamp":1535431762000},"page":"487-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Split\u2010face comparison study of transcutaneous pneumatic injection therapy with isotonic and hypertonic glucose solutions"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-5071","authenticated-orcid":false,"given":"Sung Bin","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Center, International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Korea"},{"name":"Kangskin Sillim Dermatology Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Center, International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Korea"},{"name":"Department of Dermatology Yanbian University Hospital Yanji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Ho","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Center, International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Jo","family":"Kim","sequence":"additional","affiliation":[{"name":"CNP Skin Clinic Asan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9968-9669","authenticated-orcid":false,"given":"Heesu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Center, International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon 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