{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:56:54Z","timestamp":1790812614621,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"INNOTHERA"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diosmin, a naturally occurring flavonoid, is considered as a vascular\u2010protective agent and is used orally to treat chronic venous insufficiency. It exhibits anti\u2010inflammatory and free radical scavenging properties, but, like many other flavonoids, it is poorly absorbed in the small intestine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aim was to investigate the skin protective effects of a diosmin\u2010based cream, using skin organ culture as model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fragments of human skin explants, cultured ex vivo<jats:italic>,<\/jats:italic> were allocated to four treatment groups: no cream, no cream\u00a0+\u00a0stress, placebo cream\u00a0+\u00a0stress, and 2% diosmin cream\u00a0+\u00a0stress. Stress was induced by exposure to either substance P (anti\u2010inflammatory effects\u2019 assessment) or UVB irradiation (free radical scavenging effects\u2019 assessment). Vascular dilation and the pro\u2010inflammatory mediator IL\u20108 release were determined in the first model, whereas hydrogen peroxide level and the number of cyclobutane pyrimidine\u2010positive cells were evaluated in the second model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the substance P\u2010induced inflammation model, 2% diosmin cream exhibited significant vasoconstrictive (proportion of dilated capillaries: \u221229%, capillary luminal area: \u221249% vs no cream\u00a0+\u00a0stress) and anti\u2010inflammatory (IL\u20108 release: \u221236% vs no cream\u00a0+\u00a0stress) effects. In the UVB irradiation model, 2% diosmin cream significantly reduced hydrogen peroxide production and cyclobutane pyrimidine dimer formation (\u221245% and \u221236% vs no cream\u00a0+\u00a0stress, respectively). These effects were not observed with placebo cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diosmin administered topically may protect skin against the biological effects of various exogenous or endogenous stresses, such as those involved in chronic venous disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12778","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:59:57Z","timestamp":1536627597000},"page":"848-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Anti\u2010inflammatory and antiradical effects of a 2% diosmin cream in a human skin organ culture as model"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-3986","authenticated-orcid":false,"given":"Sylvie","family":"Boisnic","sequence":"first","affiliation":[{"name":"Group of Research and Evaluation in Dermatology and Cosmetology Paris 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