{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:24:23Z","timestamp":1792787063983,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"EmCyte Corporation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n During skin aging, a degeneration of connective tissue and decrease in hyaluronic acid polymers occur. Since platelet\u2010rich plasma (\n PRP<\/jats:styled-content>\n ) contains growth factors and various cytokines, it was hypothesized that it could play a role in fibroblast activation and type I collagen expression in human fibroblasts.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n This study was performed to assess the efficacy of autologous\n PRP<\/jats:styled-content>\n injections for facial skin rejuvenation, measured by biometric instrumental evaluations and patient\u2010reported outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n Patients signed an informed consent form. The EmCyte Pure\n PRP<\/jats:styled-content>\n \u00ae<\/jats:sup>\n system technology was used to produce neutrophil\u2010poor Pure\n PRP<\/jats:styled-content>\n . The efficacy of the procedures was assessed by biometric parameters, and a patient outcome a self\u2010assessment questionnaire on each visit and at 6\u2010month follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eleven volunteers were included in the study, receiving 3 Pure\n PRP<\/jats:styled-content>\n \u00ae<\/jats:sup>\n treatments. A significant decrease in brown spot counts and area (\n P<\/jats:italic>\n \u00a0<\u00a00.05) was seen after 3\u00a0months. Wrinkle count and volume were significantly reduced (\n P<\/jats:italic>\n \u00a0<\u00a00.05 for total wrinkle appearance). Skin firmness parameters were significantly improved. Skin redness was significantly improved after 169\u00a0days post\u2010therapy for both the nasolabial and malar areas. A decrease in\n SLEB<\/jats:styled-content>\n thickness was already noted at 2\u00a0months after the first injection, with an increase in\n SLEB<\/jats:styled-content>\n density (\n P<\/jats:italic>\n \u00a0<\u00a00.05 for both parameters), without affecting subcutaneous fat thickness. Self\u2010assessment at 6\u2010month follow\u2010up revealed an average satisfaction score of >90%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n A series of 3 Pure\n PRP<\/jats:styled-content>\n injections at 6\u2010month follow\u2010up resulted in significant skin rejuvenation as demonstrated by biometric parameters and confirmed by patient self\u2010assessment score.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.12802","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T11:27:18Z","timestamp":1540294038000},"page":"985-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Autologous pure platelet\u2010rich plasma injections for facial skin rejuvenation: Biometric instrumental evaluations and patient\u2010reported outcomes to support antiaging effects"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-9380","authenticated-orcid":false,"given":"Peter A","family":"Everts","sequence":"first","affiliation":[{"name":"Gulf Coast Biologics, Research and Educational Center Fort Myers Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Contreiras","family":"Pinto","sequence":"additional","affiliation":[{"name":"PhD Trials Center Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Gir\u00e3o","sequence":"additional","affiliation":[{"name":"Clinica Dermatologica do Areeiro Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12258"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32832e9dc6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967116675272"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01188.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00708.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2014.881991"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2011.04.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(18)30699-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.4.424"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.879"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.75"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2014.949274"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1051\/ject\/200638174","article-title":"Platelet rich plasma and platelet gel: a review","volume":"38","author":"Everts PA","year":"2006","journal-title":"J Extra Corpor Technol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112800624346"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-016-9519-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.6.718"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2015-000060"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514525593"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.oto.2011.11.001"},{"key":"e_1_2_6_21_1","unstructured":"MandleR.Research study comparison of EmCyte GS30\u2010PurePRP\u00aeII EmCyte GS60\u2010PurePRP\u00aeII Arteriocyte Magellan Stryker Regenkit\u00aeTHT Eclipse PRP.Cambridge MA:Biosciences Research 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