{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:23:33Z","timestamp":1783571013705,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is an autoimmune disease with a prevalence of 1.22% in Egypt. Intralesional steroids use in localized vitiligo treatment still a matter of debate. Fluorouracil was tried in vitiligo treatment after lesion dermabrasion, ablative laser, or micro\u2010needling. The study aimed to compare the efficacy of intradermal fluorouracil and triamcinolone acetonide without any adjuvant therapy in localized vitiligo treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Sixty patients with localized non\u2010segmental stable vitiligo were assigned randomly and equally into groups. Patients subjected to intradermal injection of either fluorouracil (50\u00a0mg\/mL), triamcinolone acetonide (3\u00a0mg\/mL) or an equal mixture of both drugs. All patients had four treatment sessions every 2\u00a0weeks were followed up for 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intradermal fluorouracil showed the best overall improvement (median 52.27, IQR 36.25\u201068.18) when compared with triamcinolone (median 13.86, IQR 3.83\u201033.32) and the drug mixture (median 17.15, IQR 7.48\u201041.67). During follow\u2010up, the vitiliginous patches continued to repigment for 6\u00a0months in fluorouracil and the drug mixture groups. The improvement stopped 1\u00a0month after the last session in the triamcinolone group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The intradermal fluorouracil injection is an effective treatment of localized vitiligo. The intradermal steroid has a short\u2010acting therapeutic effect, but the mixture of drugs added no therapeutic effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12820","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T02:38:19Z","timestamp":1542335899000},"page":"1430-1434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Intradermal injection of Fluorouracil versus triamcinolone in localized vitiligo treatment"],"prefix":"10.1111","volume":"18","author":[{"given":"Hatem Abo\u2010El\u2010Wafa","family":"Zohdy","sequence":"first","affiliation":[{"name":"Faculty of Medicine Benha University Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4066-5790","authenticated-orcid":false,"given":"Mohamed Saber","family":"Hussein","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Benha University Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05377.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01936.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.5.581"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000252552"},{"key":"e_1_2_8_6_1","first-page":"308","article-title":"Vitiligo and intralesional steroids","volume":"69","author":"Vasistha LK","year":"1979","journal-title":"Indian J Med Res"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.046"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590210005001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.97"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546630902789326"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03270020012002"},{"key":"e_1_2_8_13_1","first-page":"30","article-title":"A practical method for the estimation of vitiligo surface area: a comparison between the point counting and digital planimetry techniques","volume":"17","author":"Aydin F","year":"2007","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/edm.12.32"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.031"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1979.tb15285.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1983.01650330014006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2008.00385.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/852497"},{"key":"e_1_2_8_20_1","first-page":"3","article-title":"A new important tool in the treatment of the idiopathic guttate hypomelanosis: Report of two cases","volume":"2","author":"Noriega LF","year":"2017","journal-title":"J Med Oncl Ther"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2011.579084"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03226.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/2321-8568.190142","article-title":"Comparative evaluation of the therapeutic efficacy of microneedling alone or microneedling combined with topical 5\u2010fluorouracil in localized stable childhood vitiligo","volume":"6","author":"Ghiya BC","year":"2016","journal-title":"Adv Hum Biol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.4172\/2376-0427.1000242"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4103\/ijdvl.IJDVL_386_16","article-title":"Sugareddy. 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