{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:35:22Z","timestamp":1761744922218,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The Ehlers\u2010Danlos Syndrome (EDS) can presentis a reduction in fibroblast proliferation and collagen production. Microneedling a minimally invasive technique that through mechanical stimulus there is incentive to the production of collagen and elastin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Present a case study in a patient with EDS complaining of flaccidity on large genital labia, using microneedling as a therapeutic proposal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>A 36\u2010year\u2010old female with EDS type III. The external genitalia showed tissue flaccidity associated with hyperchromia. Microneedling was performed with 0.5 mm needles and the cosmetology was used soon after the application. The level of pain was questioned to the patient through a Likert scale. The clinical response to treatment was evaluated through self\u2010report, visual analogue scale and analysis of photographic images. Five other people evaluated the results through before and after images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Microneedle was shown to be bearable in relation to pain and associated with cosmetology for tissue flaccidity due to EDS in the genital region proved to be very satisfactory for the patient, as well individuals who evaluated the comparative image.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Microneedle associated with cosmetology may be a new option for studies on skin flaccidity treatments on individuals with EDS and for treatments of genital<\/jats:p><jats:p>hyperchromias<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12867","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T08:46:50Z","timestamp":1549529210000},"page":"1336-1341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Microneedling on the external female genitalia's flaccidity in patients with Ehlers\u2010Danlos: Case report"],"prefix":"10.1111","volume":"18","author":[{"given":"T\u00e2mara","family":"Gomes","sequence":"first","affiliation":[{"name":"Bahiana School of Medicine and Public Health  Salvador Brazil"},{"name":"Pelvic Floor Care Center Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Baqueiro","sequence":"additional","affiliation":[{"name":"Bahiana School of Medicine and Public Health  Salvador Brazil"},{"name":"Pelvic Floor Care Center Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Bahiana School of Medicine and Public Health  Salvador Brazil"},{"name":"Pelvic Floor Care Center Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Alves","sequence":"additional","affiliation":[{"name":"Bahiana School of Medicine and Public Health  Salvador Brazil"},{"name":"Pelvic Floor Care Center Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-3080","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Lordelo","sequence":"additional","affiliation":[{"name":"Bahiana School of Medicine and Public Health  Salvador Brazil"},{"name":"Pelvic Floor Care Center Salvador Brazil"},{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2015.1081901"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12881"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12082"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2065-3"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"Ehlers\u2010Danlos syndrome, classical type","volume":"9999","author":"Bowen JM","year":"2017","journal-title":"Am J Med Genet Part C Semin Med Genet"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-017-0831-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20114"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198501000-00023"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjv214"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197006000-00018"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.185468"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-016-0868-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.58529"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01728.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-016-3020-x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2016.4173"},{"issue":"2","key":"e_1_2_6_19_1","first-page":"152","article-title":"Radiofrequency in the female genital laxity \u2010 a pilot study","volume":"4","author":"Lord\u00ealo P","year":"2014","journal-title":"Rev Pesquisa Fisioterapia"},{"key":"e_1_2_6_20_1","first-page":"10","article-title":"Avalia\u00e7\u00e3o dos efeitos da radiofrequ\u00eancia no tecido conjuntivo","volume":"68","author":"Carvalho GF","year":"2011","journal-title":"Revista Brasileira de Medicina"},{"issue":"1","key":"e_1_2_6_21_1","first-page":"1","article-title":"Microneedling: where do we stand now? A systematic review of the literature","volume":"71","author":"Lisa R","year":"2017","journal-title":"Br J Plast Surg"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001248"},{"key":"e_1_2_6_23_1","first-page":"158241","article-title":"Skin needling to enhance depigmenting serum penetration in the treatment of melasma","volume":"2011","author":"Fabbrocini G","year":"2011","journal-title":"Plast Surg Int"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318188245e"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12761"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000304612.72899.02"},{"issue":"1","key":"e_1_2_6_27_1","first-page":"92","article-title":"Os benef\u00edcios do microagulhamento no tratamento das disfun\u00e7\u00f5es est\u00e9ticas","volume":"3","author":"Lima AA","year":"2015","journal-title":"Rev Cient\u00edfica FHO"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000697"},{"issue":"12","key":"e_1_2_6_29_1","first-page":"1439","article-title":"Comparison between 1% tretinoin peeling versus 70% glycolic acid peeling in the treatment of female patients with melasma","volume":"10","author":"Faghihi G","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.118403"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20154748"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.12867","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T17:39:25Z","timestamp":1694021965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,7]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/jocd.12867"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12867","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2019,2,7]]},"assertion":[{"value":"2018-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}