{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:18:12Z","timestamp":1780589892048,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T00:00:00Z","timestamp":1555113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ghrelin is a 28 amino acid peptide predominantly produced by the stomach. There are many putative roles for ghrelin beyond homeostatic appetite control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the work<\/jats:title><jats:p>To determine ghrelin's level in postadolescent acne and study its relationship to plasma lipid profile, IR and acne severity and to correlate variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>This is a case\u2010control study where 50 patients with postadolescent acne and 50 age\u2010sex compatible controls were enrolled. Acne severity was assessed according to the Hayashi acne grading criteria. The parameters measured were serum level of ghrelin, fasting blood glucose, total cholesterol, low\u2010density lipoprotein, high\u2010density lipoprotein, triglycerides, and insulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean serum level of Ghrelin was significantly lower in patients compared to control group and acne severity had a significant effect on ghrelin's level. Serum levels of insulin, fasting glucose, HOMA\u2010IR, and TG were significantly increased in patients group compared to control. Serum TC, HDL, and LDL showed no significant difference between both studied groups. Ghrelin hormone had a positive correlation to HDL and a negative correlation to BMI, LDL, HOMA\u2010IR, and Insulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study postulated that low level of ghrelin may predispose patients with postadolescent acne to hyperinsulinemia, type 2 diabetes or dyslipidemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12898","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T10:54:35Z","timestamp":1555152875000},"page":"1907-1911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of low ghrelin level in patients with postadolescent acne"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2127-5535","authenticated-orcid":false,"given":"Sherine","family":"Abdel Rahman","sequence":"first","affiliation":[{"name":"Departments of Dermatology, Venerology &amp; Andrology, Faculty of Medicine Benha University Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"El Esaway","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venerology &amp; Andrology, Faculty of Medicine Benha University Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04214.x"},{"issue":"6","key":"e_1_2_8_4_1","first-page":"708","article-title":"Post\u2010adolescent acne in women: more common and more clinical considerations","volume":"11","author":"Kim GK","year":"2012","journal-title":"J Drugs 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