{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:34:34Z","timestamp":1773074074962,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81301394"],"award-info":[{"award-number":["81301394"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rosacea is a highly prevalent, chronic inflammatory disease. The treatment of rosacea remains a challenge to dermatologists. Therapies include skin care, medications, lasers, and various combinations of these modalities. The appropriate treatment depends on clinical types and patient's various clinical symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study was to review and compare current therapies for rosacea of all severities from four different guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>We searched PubMed using the keywords \u201crosacea,\u201d \u201ctreatment\u201d AND [\u201cerythema rosacea\u201d OR \u201cpapulopustular rosacea\u201d OR \u201cocular rosacea\u201d OR \u201cphymatous rosacea\u201d]. We selected randomized controlled trials, observational studies, controlled clinical trials, and clinical trials. We indentified further studies (including the guidelines) by hand\u2010searching relevant publications and included those that met the inclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total number of records identified was 421. We limited our search to the specific abovementioned study types. Twenty\u2010five of these studies met with our inclusion criteria. An additional five manuscripts were selected using the abovementioned method, and four guidelines were included in this review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diagnosing and choosing the appropriate treatment options of rosacea according to guidelines is the basis of scientific criteria. More large\u2010scale randomized controlled clinical trials on new treatment methods, new drugs, or new dosage forms provide a new guideline for future rosacea treatment. Although there are some differences in the treatment of rosacea, it is generally based on anti\u2010demodex, anti\u2010inflammatory, and anti\u2010angiogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12903","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T04:25:23Z","timestamp":1551241523000},"page":"960-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Global rosacea treatment guidelines and expert consensus points: The differences"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-923X","authenticated-orcid":false,"given":"Juliandri","family":"Juliandri","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Skin &amp; Cosmetic Research Shanghai Skin Disease Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,26]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"156","article-title":"Diagnosis and treatment of rosacea in China: an expert consensus statement (2016)","volume":"50","author":"Xie","year":"2017","journal-title":"Chin J Dermatol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475416650427"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14349"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15173"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.04.002"},{"key":"e_1_2_5_7_1","first-page":"56","article-title":"Long\u2010term safety and efficacy of once\u2010daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of a 1\u2010year open\u2010label study","volume":"13","author":"Moore A","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.04.017"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200101000-00006"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10473.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01223.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02822.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338693"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3215027532"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2017.1370370"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.59.8.0010"},{"key":"e_1_2_5_17_1","first-page":"964","article-title":"Azelaic acid: evidence\u2010based update on mechanism of action and clinical application","volume":"14","author":"Schulte BC","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14437"},{"key":"e_1_2_5_19_1","first-page":"685","article-title":"Randomized, phase 2, dose\u2010ranging study in the treatment of rosacea with encapsulated benzoyl peroxide gel","volume":"13","author":"Leyden JJ","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_20_1","first-page":"573","article-title":"Comparison of anti\u2010inflammatory dose doxycycline versus doxycycline 100 mg in the treatment of rosacea","volume":"7","author":"Rosso JQ","year":"2008","journal-title":"J Drugs Dermatol"},{"issue":"6","key":"e_1_2_5_21_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/ddg.13141","article-title":"State of the art: systemic rosacea management","volume":"14","author":"Schaller M","year":"2016","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_5_22_1","first-page":"153","article-title":"Improvement in the understanding of rosacea","volume":"50","author":"Zhi\u2010Qiang H","year":"2017","journal-title":"Chin J Dermatol"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.09.005"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.034"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T21:34:31Z","timestamp":1694295271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,26]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/jocd.12903"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12903","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,26]]},"assertion":[{"value":"2018-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}