{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:49:27Z","timestamp":1790765367852,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["7176"],"award-info":[{"award-number":["7176"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic wound or nonhealing ulcer is essentially a wound that does not progress normally through the wound healing process. This study assessed the healing effect of umbilical cord Wharton's jelly stem cells seeded on biological scaffold in chronic skin ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In a randomized clinical trial, five patients between 30 and 60\u00a0years with chronic diabetic wounds were enrolled. To cover the wounds, acellular amniotic membrane seeded with Wharton's jelly mesenchymal stem cells (WJSCs) was used for 9\u00a0days, every 3\u00a0days with a follow\u2010up of 1\u00a0month. The percentage and time of wound healing and the size of wound were recorded for each patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In treated patients, the wound healing time and wound size significantly decreased, and after 6 and 9\u00a0days, the wound size significantly declined (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As WJSCs seeded on amniotic membrane could significantly accelerate the healing effect in chronic diabetic wounds, they can be an alternative source in tissue engineering and repair of chronic ulcers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12931","type":"journal-article","created":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T05:40:30Z","timestamp":1558762830000},"page":"1961-1967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["The healing effect of Wharton's jelly stem cells seeded on biological scaffold in chronic skin ulcers: A randomized clinical trial"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9395-9573","authenticated-orcid":false,"given":"Seyedeh\u2010Sara","family":"Hashemi","sequence":"first","affiliation":[{"name":"Burn and Wound Healing Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Akbar","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Burn and Wound Healing Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Kabiri","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Hashempoor","sequence":"additional","affiliation":[{"name":"Burn and Wound Healing Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdokht","family":"Mahmoodi","sequence":"additional","affiliation":[{"name":"Burn and Wound Healing Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9725-7026","authenticated-orcid":false,"given":"Masood","family":"Amini","sequence":"additional","affiliation":[{"name":"Minimal Invasive Laparascopy Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5738-1719","authenticated-orcid":false,"given":"Davood","family":"Mehrabani","sequence":"additional","affiliation":[{"name":"Burn and Wound Healing Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Rohan Gene Cell Tech Center Shiraz 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