{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:21:02Z","timestamp":1771946462287,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is a common chronic inflammatory skin disease involving pilosebaceous units. Both innate and adaptive immunity, especially the T helper 17 pathway, may contribute to the inflammatory response in acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed at evaluation of serum interleukin\u201017 (IL\u201017) level in patients with acne vulgaris in order to assess its role in disease pathogenesis and its clinical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum IL\u201017 level was measured by an ELISA technique in 80 acne vulgaris patients and 80 apparently healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum IL\u201017 level was significantly higher in acne vulgaris patients than control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Moreover, it was increasing significantly with the increase in disease severity and in patients with scarring lesions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 each).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum IL\u201017 is not only a biomarker of disease pathogenesis but also it could be a potential prognostic predictor for severity and scarring in acne vulgaris.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12934","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T11:13:36Z","timestamp":1554808416000},"page":"1975-1979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Serum interleukin\u201017 as a novel biomarker in patients with acne vulgaris"],"prefix":"10.1111","volume":"18","author":[{"given":"Adel A.","family":"Ebrahim","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3877-5787","authenticated-orcid":false,"given":"Amany Ibrahim","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awad Mohamed","family":"El\u2010Abd","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"43.1","volume-title":"Textbook of Dermatology","author":"Cunliffe 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