{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:33:47Z","timestamp":1747186427219,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is an inflammatory disorder with a profound heterogenous aetio\u2010pathophysiology. ACE gene I\/D polymorphism affects angiotensin\u2010converting enzyme activities that play a role in inflammation. However, there are no molecular genetic studies investigating the contribution of ACE gene insertion\/deletion polymorphism in the genetic background of acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this work was to reveal the relation between the ACE gene I\/D polymorphism and acne vulgaris development among a sample of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This study included 100 acne vulgaris patients in addition to 120 matched control subjects. The ACE gene I\/D polymorphism was analyzed using polymerase chain reaction (PCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of DD, ID genotypes, and D allele showed higher frequency in AV patients than in controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 for all). Moreover, positive family history and ACEI\/D gene polymorphism (DD\u00a0+\u00a0ID genotypes) were considered as independent predictors for severe acne grades (<jats:italic>P\u00a0<\/jats:italic>\u2264\u00a00.001 and 0.046, respectively) in multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current study results suggest that the D allele of the ACE I\/D gene polymorphism might confer risk to AV among the studied patients. Moreover, ACE I\/D gene polymorphism and positive family history were considered as independent predictors of severe AV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12937","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T13:12:00Z","timestamp":1556629920000},"page":"1992-1997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Angiotensin\u2010converting enzyme gene insertion\/deletion polymorphism and family history in severe acne vulgaris"],"prefix":"10.1111","volume":"18","author":[{"given":"Neveen E.","family":"Sorour","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Dermatology, Venereology and Andrology Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3877-5787","authenticated-orcid":false,"given":"Amany 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