{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:08:30Z","timestamp":1774015710299,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fractional carbon dioxide (FrCO<jats:sub>2<\/jats:sub>) laser is effective for atrophic acne scar treatment, but unavoidable downtime. Meanwhile, postoperative topical steroid decreases the downtime, yet still possibly increases other steroid side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper\u2010zinc\u2010manganese (experimental cream) versus 0.02% Triamcinolone acetonide (TA) cream in decreasing adverse effects and downtime after FrCO<jats:sub>2<\/jats:sub> laser, with wound healing improvement and prevention of certain steroid\u2010related side effects like postinflammatory hyperpigmentation (PIH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a double\u2010blinded, split face, randomized controlled trial in 20 subjects receiving FrCO<jats:sub>2<\/jats:sub> laser on both sides of the faces and randomly treated with two posttreatment regimens on each side for 7\u00a0days. Clinical, expert panel assessment of photography, downtime, side effects, and biometric evaluation for erythema and melanin were performed on baseline, immediately after treatment, day 3, 5, 7, 14, 30 and, 60 postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both experimental cream (EC) and 0.02% TA cream could significantly reduce postlaser downtime including swelling, redness, crusting, and scaling in 5\u20107\u00a0days, with comparable efficacies in decreasing downtime and adverse reactions, as well as wound healing improvement and lower PIH without statistically significant difference between the two treatments. The incidence of PIH was 60% in the EC treated group with minimal intensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The moisturizer with anti\u2010inflammatory ingredients could be a novel treatment modality for reduction of postablative laser downtime by using nonsteroidal anti\u2010inflammatory agents to avoid adverse effects and improve wound healing process with lower PIH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12951","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T07:35:48Z","timestamp":1554363348000},"page":"1751-1757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper\u2010zinc\u2010manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split\u2010face, double\u2010blinded, randomized, controlled trial"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-2982","authenticated-orcid":false,"given":"Suparuj","family":"Lueangarun","sequence":"first","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University Pathumthani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aphinut","family":"Srituravanit","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University Pathumthani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therdpong","family":"Tempark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"3021","volume-title":"Ablative Lasers, Chemical Peels, and Dermabrasion. Fitzpatrick\u2019s Dermatology in General Medicine","author":"Lowell A","year":"2012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.051"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12050"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1899"},{"key":"e_1_2_10_6_1","unstructured":"CrickxB LacourJ ArsanA AssathianyR SeiteS FayolleC.A french observational study on the management of epidermal wound healing. Poster presented at: Skin is Vital. 21st European Academy of Dermatology and Venereology 27\u201330. Prague CZ; 2012 Sep."},{"key":"e_1_2_10_7_1","unstructured":"SeiteS RougierA ZelenkovaH.Interest of madecassoside in the treatment of atopic dermatitis lesion: a randomized double-blind placebo-controlled clinical study. Poster presented at: Skin is Vital. 21st European Academy of Dermatology and Venereology 27\u201330. 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