{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:20:32Z","timestamp":1768033232522,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Progranulin (PGRN) is a secreted glycoprotein that was investigated in many skin diseases. It plays an important role in inflammatory response and autophagy which could be mediated through Wnt\/\u03b2\u2010catenin pathway. However, the role of PGRN in pathogenesis of psoriasis has not been clearly well\u2010known. Therefore, we aimed by this study to investigate the possible role of progranulin in psoriasis pathogenesis through evaluation of its immunohistochemical expression in lesional and perilesional skin of psoriasis patients and to investigate if its hypothesized role is mediated through \u03b2\u2010catenin or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2010control study was carried out on 37 patients presented with variable degrees of psoriasis vulgaris severity vs 37 age and sex\u2010matched apparently healthy volunteers. Psoriasis area and severity index (PASI) score was used to evaluate the severity of psoriasis. From all cases (lesional and perilesional) and controls, skin biopsies were taken for histopathological and immunohistochemical evaluation of PGRN and \u03b2\u2010catenin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant stepwise upregulation of PGRN from controls (76.2\u00a0\u00b1\u00a011.9) to perilesional (178.7\u00a0\u00b1\u00a011.8) and lesional (242.7\u00a0\u00b1\u00a012.7) psoriatic skin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). PGRN expression was significantly correlated with psoriasis severity (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.61; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). \u03b2\u2010catenin showed a significant stepwise downregulation from control (210.0\u00a0\u00b1\u00a019.3) to perilesional (131.4\u00a0\u00b1\u00a09.2) and lesional (97.3\u00a0\u00b1\u00a011.5) psoriatic skin(<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). There was a significant negative correlation between PGRN and \u03b2\u2010catenin expression in psoriatic skin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Progranulin has a pro\u2010inflammatory effect in the psoriasis pathogenesis, which could be mediated through a decreasing \u03b2\u2010catenin expression in psoriasis. PGRN may be used as a target for immunotherapy in psoriasis management program.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12966","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T12:44:44Z","timestamp":1557924284000},"page":"2019-2026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Progranulin and beta\u2010catenin in psoriasis: An immunohistochemical study"],"prefix":"10.1111","volume":"18","author":[{"given":"Azza Gaber Antar","family":"Farag","sequence":"first","affiliation":[{"name":"Department of Dermatology, Andrology and STDs, Faculty of Medicine Menoufia University Shebin El Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Abdalmoneim","family":"Shoaib","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andrology and STDs, Faculty of Medicine Menoufia University Shebin El Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehab Mounir","family":"Samaka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Menoufia University Shebin El Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-2937","authenticated-orcid":false,"given":"Asmaa Gaber","family":"Abdou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Menoufia University Shebin El Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa Mahmoud","family":"Mandour","sequence":"additional","affiliation":[{"name":"Resident Dermatology at Ministry of Health Menoufia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda Abdel Latif","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Public Health and Community Medicine, Faculty of Medicine Menoufia University Shebin El Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.11.001"},{"issue":"2","key":"e_1_2_5_3_1","first-page":"117","article-title":"Study of tumour necrosis factor\u2010\u03b1\u2010308 promotor polymorphism in psoriasis vulgaris","volume":"11","author":"El\u2010Farargy S","year":"2014","journal-title":"JEWDS"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.008"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.08.012"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1580145"},{"issue":"4","key":"e_1_2_5_7_1","first-page":"1275","article-title":"Progranulin (granulin\u2010epithelin precursor, PC\u2010cellderived growth factor, acrogranin) in proliferation and tumorigenesis","volume":"18","author":"Ong S","year":"2003","journal-title":"Histol Histopathol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-65"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.399170"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.04.037"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04968.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R600027200"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2008.73.011"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.20.7391-7402.2003"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0370-y"},{"issue":"5","key":"e_1_2_5_16_1","first-page":"48","article-title":"Psoriasis","volume":"11","author":"Kerkhof PC","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12761"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-4-22"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2878"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540004800713"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-003-0474-3"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12446"},{"key":"e_1_2_5_23_1","first-page":"46","article-title":"The histopathology of psoriasis","volume":"46","author":"Chiara M","year":"2007","journal-title":"Reumatismo"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4087"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.12.002"},{"issue":"13","key":"e_1_2_5_26_1","first-page":"541","article-title":"IL\u20106 as a druggable target in psoriasis: focus on pustular variants","volume":"137","author":"Andrea S","year":"2014","journal-title":"J Immunol Res"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01141-8"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199214"},{"issue":"1","key":"e_1_2_5_29_1","first-page":"55","article-title":"Immunohistochemical expression of beta\u2010catenin in psoriasis","volume":"80","author":"Mahfouz SM","year":"2012","journal-title":"Med J Cairo Univ"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03318.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.148923"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364351"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1175-06.2006"},{"key":"e_1_2_5_34_1","first-page":"22","article-title":"Progranulin protect against osteoarthritis through interacting with TNF\u2010alpha and beta\u2010catenin signaling","volume":"74","author":"Zaho YP","year":"2015","journal-title":"Ann Rheum Dis"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.12966","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:19:38Z","timestamp":1694164778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,15]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/jocd.12966"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12966","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,15]]},"assertion":[{"value":"2018-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}