{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:49:51Z","timestamp":1792122591703,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This study was supported by TUBITAK.","award":["BIDEP-2209 A- Number:1919B011604047"],"award-info":[{"award-number":["BIDEP-2209 A- Number:1919B011604047"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>UV filters should be determined a strict toxicological safety prior to approval. Homosalate (HMS) is one of the most widely used organic UV filter. HMS accumulates in aquatic biota ecosystems and humans through the food chain; therefore, it is important to consider the effects on health and know its mechanisms of action.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The study aimed to evaluate the cytotoxic and genotoxic effects of HMS in MCF\u20107 cell line.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cell viability was examined by the 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)2,5\u2010diphenyl tetrazolium bromide (MTT) and cell membrane integrity by the lactate dehydrogenase release assays (LDH), and genotoxicity by using the micronucleus test at 250, 500, 750, 1000, 1500, and 2000\u00a0\u00b5M concentrations with the human breast cell line MCF\u20107.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Homosalate affected the cell viability dose\u2010dependently at a concentrations of above 1000\u00a0\u00b5M. Micronucleus formation was significantly induced at 750 and 1000\u00a0\u00b5M within 24\u00a0hours due to an increase in cytostatic effect, the cell viability of HMS decreased to 57% at a concentration of 2000\u00a0\u00b5M, and a sufficient number of binucleated cells could not be obtained to count. Homosalate was also clastogenic when the cells were incubated at cytotoxic concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that homosalate can be considered as a cytotoxic and genotoxic substance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12973","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T10:09:04Z","timestamp":1556186944000},"page":"246-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Assessment of the cytotoxicity and genotoxicity of homosalate in MCF\u20107"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2626-4066","authenticated-orcid":false,"given":"Selma","family":"Yazar","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Toxicology Istanbul YeniYuzyil University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-7057","authenticated-orcid":false,"given":"Simge","family":"Kara Ertekin","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Toxicology Istanbul YeniYuzyil University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2015.03.026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-82502013000200002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2013.861376"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/9781849731102"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.01109239"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph13080782"},{"key":"e_1_2_8_8_1","first-page":"2110","article-title":"Activation of alpha, beta estrogen, pS2 and AHR receptors by UV filters in MCF\u20107 cell line","volume":"27","author":"Yazar S","year":"2018","journal-title":"Fresen Environ Bull"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2013.05.036"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10646-013-1161-y"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2016.1206148"},{"key":"e_1_2_8_12_1","first-page":"7","article-title":"Toxicological profile of homosalate as cosmetic ingredients","volume":"1","author":"Urek SY","year":"2013","journal-title":"Global J Pathol Microbiol"},{"key":"e_1_2_8_13_1","first-page":"472","article-title":"Investigation of genotoxicity of homosalate byproducts occured in the presence of free chlorine by using Allium Test","volume":"8","author":"Imamovi\u0107 B","year":"2016","journal-title":"Int J Collab Res Internal Med Public Health"},{"key":"e_1_2_8_14_1","first-page":"436","article-title":"Assessment of in vitro genotoxicity effect of homosalate in cosmetics","volume":"22","author":"Yazar S","year":"2018","journal-title":"Marmara Pharm J"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.07.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx700365e"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-016-9998-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41021-016-0044-x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/17.4.345"},{"key":"e_1_2_8_20_1","first-page":"23159","article-title":"Cytokinesis\u2010block micronucleus assay in human glioma cells exposed to radiation","author":"Slowinski J","year":"2011","journal-title":"Image Anal Stereol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(93)90049-L"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph2007040006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2011.647181"},{"key":"e_1_2_8_24_1","unstructured":"SevincD.Investigation of the cytotoxic and genotoxic effects of some sunscreeen compounds on healthy cell culture. 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