{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:40:44Z","timestamp":1772160044311,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While a considerable number of cases with papulopustular rosacea (PPR) are resistant to conventional medications, therapeutic regimens are not currently established. Pulsed dye laser (PDL) and fractional microneedling radiofrequency (FMR) have previously demonstrated satisfactory results for anti\u2010angiogenesis, anti\u2010inflammation, and dermal remodeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the efficacy and safety of novel combination regimen with low\u2010dose oral isotretinoin, PDL, and FMR in the treatment of recalcitrant PPR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A retrospective study was undertaken for recalcitrant PPR patients to evaluate the clinical course of novel combination regimen. Twenty\u2010five PPR patients who had failed in previous first\u2010line therapies were enrolled. They were treated with three sessions of PDL and FMR consecutively at 4\u2010week intervals, maintaining daily oral administration of 10\u00a0mg isotretinoin for 8\u00a0weeks. Objective assessments, erythema index measurement, and patients\u2019 subjective satisfaction were evaluated at each visit and 16\u00a0weeks after the final treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the final follow\u2010up visit, the number of papules and pustules decreased by 71%, and erythema index by 54% compared with baseline (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 for both). Physician\u2019s global assessment based on rosacea severity score and patients\u2019 subjective assessments paralleled with these results. No serious side effect was observed during whole study periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This novel combination regimen demonstrated satisfactory efficacy with reasonable safety profiles for the treatment of recalcitrant PPR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12982","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T07:59:48Z","timestamp":1558166388000},"page":"105-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Combined treatment of recalcitrant papulopustular rosacea involving pulsed dye laser and fractional microneedling radiofrequency with low\u2010dose isotretinoin"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8194-1790","authenticated-orcid":false,"given":"Hyuck Hoon","family":"Kwon","sequence":"first","affiliation":[{"name":"Oaro Dermatology Clinic Seoul 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