{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:46:00Z","timestamp":1770511560228,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mesotherapy for chronoaged skin shows heterogeneous results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to assess the efficacy of dermal redensification on the face and neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with mild\u2010moderate\u2010severe chronoaging of face and neck were included and, every 14\u00a0days, treated with four sessions of dermal redensification, consisting of 1\u00a0mL of hyaluronic acid (15\u00a0mg\/mL) plus a dermo\u2010restructuring complex. Skin improvements were analyzed at 8\u00a0weeks for amelioration by Wrinkle Severity Rating Scale and quantification of superficial wrinkles and texture by high\u2010resolution 3D camera. All patients underwent a self\u2010assessment questionnaire and Global Aesthetic Improvement Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six patients were enrolled (median age 55 [42\u201067] years). Eight weeks after treatment all patients reported a significant improvement, being Global Aesthetic Improvement Scale \u22652 in 69% of the subjects. Patients\u2019 perception of improvement of their skin quality was highly satisfactory in all items explored on the self\u2010assessment questionnaire relating to radiance, elasticity, texture, and smoothness. Subjects with fine and moderate\/deep wrinkles had an improvement &gt;25% and 50%, respectively. Quantification of wrinkles with filters for superficial plane (1\u00a0mm) showed a statistically significant median decrease, both in width (1.53 [1.41\u20101.72] mm vs 1.27 [1.12\u20101.34] <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and depth (0.46 [0.27\u20100.61] vs 0.12 [0.6\u20100.18] <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Indentation decreased by a median of 20%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The synergic effects of hyaluronic acid and dermo\u2010restructuring complex show an objective amelioration of skin texture, wrinkles, and self\u2010evaluation of skin appearance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12984","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T13:38:37Z","timestamp":1557581917000},"page":"199-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of dermal redensification in chronoaged face: Quantitative volumetric assessment"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8187-011X","authenticated-orcid":false,"given":"Cristina M.","family":"D\u2019Aloiso","sequence":"first","affiliation":[{"name":"Aesthetic Medicine Clinic Padua 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