{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:14:31Z","timestamp":1782695671652,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne is a common condition that affects up to 80% of all adolescents. Scarring may affect some 95% as a function of severity and delay before treatment. The pathogenesis includes enzymatic degradation of collagen fibers and subcutaneous fat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to treat atrophic acne scars using the Dual\u2010Plane injection of Hyaluronic Acid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 12 patients with moderate\u2010to\u2010severe atrophic acne scars were treated with a novel NAHYCO\u2122 based Hyaluronic Acid filler, using a dual\u2010plane technique for two treatment sessions at a 4\u2010week interval. Results were objectively assessed by two blinded Dermatologists and subjectively evaluated by the patients themselves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8 out of the 12 patients reported moderate improvement, two indicated marked improvement and two rated minimal improvement. Dermatologists' mean global evaluation score was 2.5\u00a0\u00b1\u00a00.43.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>The small sample size and regional nature of a single\u2010center study. Nevertheless, both the expert dermatologists' and the patients' evaluations of standardized high\u2010resolution medical photographs were consistent, suggesting that this inherent bias was negligible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The treatment led to impressive improvement in the depth of the scars, suggesting that this technique can result in safe and rapid amelioration of atrophic acne scars in only two sessions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12991","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T08:49:59Z","timestamp":1557478199000},"page":"69-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Dual\u2010plane hyaluronic acid treatment for atrophic acne scars"],"prefix":"10.1111","volume":"19","author":[{"given":"Ofir","family":"Artzi","sequence":"first","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarit","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Assaf Harofeh Medical Center Zeriffin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Koren","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Dr. Artzi Clinic and Research Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni","family":"Niv","sequence":"additional","affiliation":[{"name":"Dr. Artzi Clinic and Research Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-7909","authenticated-orcid":false,"given":"Or","family":"Friedman","sequence":"additional","affiliation":[{"name":"The Plastic and Reconstructive Surgery Department, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"50","article-title":"Practical evaluation and management of atrophic acne scars: tips for the general dermatologist","volume":"4","author":"Fife D","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113451"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-012-0011-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03291.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-008-9242-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.99232.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00239.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2005.10.020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/893080"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-09424-3_9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-8344-1_34"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-013-0043-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1980.tb00897.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2009.02.014"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12390"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2098"},{"key":"e_1_2_8_19_1","unstructured":"DeRosaM D'AgostinoA LaGattaA SchiraldiC.Hybrid cooperative complexes of hyaluronic acid. 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