{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T23:56:25Z","timestamp":1778370985852,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To know the pain intensity experienced by the patients using the two different syringes keeping the needle size constant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The split\u2010scalp, single\u2010blind study was conducted in patients after obtaining informed consent. On half of side, 1\u2010mL syringe with 30\u2010G needle was used whereas on the other half, 3\u2010mL syringe with 30\u2010G needle was used. On each side, about 10\u00a0mL of anesthetic solution (1% Xylocaine with epinephrine in 1:100\u00a0000 dilution) at the room temperature was injected. After the injections, the patients were asked to rate the pain experienced by using the Wong\u2010Baker Faces pain scale. The data were analyzed statistically using Mann\u2010Whitney\u2019s <jats:italic>U<\/jats:italic> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 20 patients included 16 male and 4 females. The mean age in the males was 31.6\u00a0years and 28.8\u00a0years in females. The mean pain scale with 1\u2010mL syringe was 2.7 anteriorly and 2.45 posteriorly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), whereas the mean pain score with 3\u2010mL syringe was 4.5 anteriorly and 4.25 posteriorly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><jats:p>The mean pain score with anterior injections in males was 2.5 vs 3.5 in females (1\u2010mL syringe) and 4.3 in males vs 5.5 in females (1\u2010mL syringe). Similarly, the average pain score with posterior injections was 2.4 in males vs 2.8 in females (1\u2010mL syringe) and 4.2 in males vs 4.5 in females (3\u2010mL syringe), respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The pain intensity is affected by syringe size.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12993","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T18:16:22Z","timestamp":1558030582000},"page":"1856-1859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of syringe size on severity of pain during local anesthesia administration"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0251-688X","authenticated-orcid":false,"given":"Muhammad","family":"Ahmad","sequence":"first","affiliation":[{"name":"Plastic &amp; Hair Restoration Surgeon Aesthetic Plastic Surgery &amp; Hair Transplant Institute Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"issue":"6","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.33589\/20.6.0190","article-title":"Patients\u2019 experience of Supra\u2010orbital\/supra\u2010trochlear nerve blocks in hair transplant surgery","volume":"20","author":"Ahmad M","year":"2010","journal-title":"Hair Transpl Forum Intl"},{"issue":"3","key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.33589\/22.3.0084","article-title":"The efficacy of supraorbital\/supratrochlear nerve blocks in hair transplant surgery. Past II: the use of local anaesthetic cream","volume":"22","author":"Ahmad M","year":"2012","journal-title":"Hair Transpl Forum Intl"},{"issue":"1","key":"e_1_2_5_4_1","first-page":"19","article-title":"Nerve blocks OR subcutaneous injections: comparison of pain levels in patients undergoing hair transplant surgery","volume":"4","author":"Ahmad M","year":"2015","journal-title":"Pak J Plast Surg"},{"issue":"4","key":"e_1_2_5_5_1","first-page":"555595","article-title":"\u2018Supraorbital\/supratrochlear nerve blocks: clinical significance of the superior and anterior approaches","volume":"2","author":"Ahmad M","year":"2017","journal-title":"J Anaesthesia Intensive Care Med"},{"issue":"3","key":"e_1_2_5_6_1","first-page":"247","article-title":"Use of vibration anesthesia in hair restoration surgery","volume":"27","author":"Ahmad M","year":"2017","journal-title":"J Pak Assoc Dermatol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9625-y"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.38293"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01100.x"},{"issue":"7","key":"e_1_2_5_10_1","first-page":"77","article-title":"Technical considerations in the development of prefilled syringes for protein products","volume":"9","author":"Overcashier DE","year":"2006","journal-title":"Am Pharm Rev"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-8-38"},{"key":"e_1_2_5_12_1","unstructured":"www.wongbakerfaces.org. Accessed on 01\u201303\u20102018."},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5162394"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12869"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0991"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181b1e526"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/08990220600700925"},{"key":"e_1_2_5_18_1","volume-title":"Extrusion force and syringe dimensions of two Hyaluronic acid dermal fillers","author":"Ohrlund A"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.12993","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:18:55Z","timestamp":1694164735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,16]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/jocd.12993"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12993","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,16]]},"assertion":[{"value":"2018-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}