{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:52:00Z","timestamp":1765486320814,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>TWEAK is an inflammatory cytokine which is involved in the development of many inflammatory disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to evaluate serum levels of TWEAK in patients with acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>This case\u2010controlled study included 100 acne vulgaris patients divided into two groups. Group 1 included 25 patients with moderate acne and 25 patients with severe acne. Group 2 consisted of 50 acne\u2010free control subjects. Acne was graded by the Global Acne Grading System (GAGS). Serum TWEAK was measured by ELISA kits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acne patients had significant elevation in TWEAK serum levels when compared to the control subjects (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). TWEAK serum levels did not show significant difference regarding disease grade, postacne scar, and hyperpigmentation (<jats:italic>P<\/jats:italic> value\u00a0=\u00a00.43, 0.37, 0.80, 0.67, respectively)<jats:bold>.<\/jats:bold> TWEAK levels were not affected by any of the studied variables except for the significant negative correlation between its levels and the disease duration in severe acne group only (<jats:italic>r\u00a0<\/jats:italic>=\u00a0\u22120.42, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03)<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TWEAK may be involved in acne vulgaris development, but more studies are needed to clarify its role.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13011","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T09:14:33Z","timestamp":1559034873000},"page":"514-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum TWEAK in acne vulgaris: An unknown soldier"],"prefix":"10.1111","volume":"19","author":[{"given":"Abd El\u2010Aziz Ibrahim","family":"El\u2010Taweel","sequence":"first","affiliation":[{"name":"Department of Dermatology and Andrology, Faculty of Medicine Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-1224","authenticated-orcid":false,"given":"Rehab Mohammed","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Andrology, Faculty of Medicine Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira Mohamed Noureldin","family":"Abdelrahman","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Faculty of Medicine Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basma Abd El\u2010Kafy","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Dermatology Resident at Ministry of Health Hospital Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.09.001"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"25","article-title":"Addressing free radical oxidation in acne vulgaris","volume":"9","author":"Mills OH","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12957"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01762.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.05.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"issue":"1","key":"e_1_2_7_8_1","first-page":"69","article-title":"Protocol for evaluation of automated blood cell counters. 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