{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:38:23Z","timestamp":1779233903595,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371746"],"award-info":[{"award-number":["81371746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photodynamic therapy (PDT) with 5\u2010aminolevulinic acid (ALA) has been described as an effective treatment for severe acne. However, very little evidence exists on the optimal concentration of ALA used in PDT for severe acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy and safety of PDT with 5% ALA vs 10% ALA in severe acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three patients with severe facial acne were randomly assigned to receive PDT with 5% ALA or 10% ALA on the left or right side of the face. Four PDT sessions were conducted with a light dose of 96\u00a0J\/cm<jats:sup>2<\/jats:sup>. The reduction rates of lesion counts between the two groups were compared at the week\u20104 and week\u201012 follow\u2010up visits. Effective rate at the week\u201012 visit was the primary clinical outcome. Pain and other side effects were evaluated at each visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The decrease in inflammatory lesions in the 10% ALA group was greater than that in the 5% ALA group at both week\u20104 (79.2% vs 62.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) and week\u201012 follow\u2010up visits (88.5% vs 78.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018), while the decrease in noninflammatory lesion counts between the two groups was not statistically significant at each follow\u2010up visit. The effective rate in the 10% ALA group was significantly higher than that in the 5% ALA group (95.7% vs 69.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). No significant difference was observed in pain scores between the two groups except in the first treatment session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Photodynamic therapy using 10% ALA was more effective for severe acne than PDT using 5% ALA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13038","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T09:44:00Z","timestamp":1560332640000},"page":"368-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Photodynamic therapy for severe facial acne vulgaris with 5% 5\u2010aminolevulinic acid vs 10% 5\u2010aminolevulinic acid: A split\u2010face randomized controlled study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7068-9814","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology The Third Affiliated Hospital of Sun, Yat\u2010sen University Guangzhou Guangdong Province China"},{"name":"Department of Dermatology and Venereology Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Venereology Dermatology Hospital of Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen Children\u2019s Hospital Guangzhou Guangdong Province 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