{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:37:12Z","timestamp":1757450232917,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2815-C-214-004-B","106-2221-E-214-015"],"award-info":[{"award-number":["105-2815-C-214-004-B","106-2221-E-214-015"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Farnesol is an acyclic sesquiterpene presents in various natural sources including fruits, vegetables, and herbs. In this study, we successfully prepared a farnesol\u2010containing gel with ultraviolet B\u2010screening and skin\u2010repairing capabilities. Furthermore, the advantageous potential of farnesol\u2010containing facial masks for UVB\u2010caused sunburnt skin was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Thus, the objectives of this study are to design and prepare optimal facial masks possessing collagen production and smoothness\u2010enhancing capabilities for the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A series of formulations consisting of hydroxypropyl methylcellulose, hyaluronan, and farnesol were used to prepare the facial masks. The effects of the facial masks on collagen production by skin fibroblasts in vitro were examined. The effects of the prepared masks on collagen synthesis, smoothness, and inflammation of the skin were further evaluated in vivo using two modes (mask administration interspersed with UVB exposure and mask administration after UVB exposure) of a rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Facial masks containing both 0.3 and 0.8\u00a0mM farnesol improved skin smoothness and enhanced collagen content and arrangement in the skin of rats with mask administration interspersed with and after UVB exposure. The masks containing 0.8\u00a0mM farnesol exerted the greatest effects on collagen production\/arrangement and smoothness improvement in vivo model. Histopathologically observed inflammation was alleviated, and interleukin (IL)\u20106 was decreased in the 0.8\u00a0mM farnesol\u2010containing facial mask\u2010covered skin compared with that without facial masks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The farnesol\u2010containing facial masks prepared in this study may have collagen production\u2010increasing, smoothness\u2010improving, and anti\u2010inflammatory properties for UVB\u2010caused sunburn; thus, farnesol is potentially a beneficial component in facial masks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13046","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T07:58:05Z","timestamp":1561622285000},"page":"540-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antiaging and smoothness\u2010improving properties of farnesol\u2010based facial masks on rat skin exposed to ultraviolet B"],"prefix":"10.1111","volume":"19","author":[{"given":"Yu Wen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering I\u2010Shou University Kaohsiung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Hsiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine National Chiayi University Chiayi City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan Xuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering I\u2010Shou University Kaohsiung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huoy Rou","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering I\u2010Shou University Kaohsiung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun Lieh","family":"Wu","sequence":"additional","affiliation":[{"name":"Bioptik Technology, INC Miaoli County Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0706-398X","authenticated-orcid":false,"given":"Shyh Ming","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering I\u2010Shou University Kaohsiung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1016\/j.pain.2006.12.014"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1016\/j.pain.2012.12.020"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1007\/s10522-017-9715-7"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1038\/srep37403"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1016\/j.jaad.2017.01.044"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1016\/j.jphotobiol.2014.02.019"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.1016\/j.ceramint.2017.11.028"},{"doi-asserted-by":"publisher","key":"e_1_2_5_9_1","DOI":"10.3390\/ijms17091521"},{"doi-asserted-by":"publisher","key":"e_1_2_5_10_1","DOI":"10.1111\/phpp.12297"},{"doi-asserted-by":"publisher","key":"e_1_2_5_11_1","DOI":"10.1111\/j.1365-2958.2007.05840.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_1","DOI":"10.1007\/s11745-008-3192-3"},{"doi-asserted-by":"publisher","key":"e_1_2_5_13_1","DOI":"10.1016\/j.cbi.2011.03.009"},{"doi-asserted-by":"publisher","key":"e_1_2_5_14_1","DOI":"10.1007\/s11010-005-3178-x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_15_1","DOI":"10.1002\/jcb.20782"},{"doi-asserted-by":"publisher","key":"e_1_2_5_16_1","DOI":"10.1007\/s00441-014-1893-x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_17_1","DOI":"10.1208\/s12249-010-9475-z"},{"doi-asserted-by":"publisher","key":"e_1_2_5_18_1","DOI":"10.4161\/derm.21923"},{"doi-asserted-by":"publisher","key":"e_1_2_5_19_1","DOI":"10.1080\/14764172.2018.1502454"},{"doi-asserted-by":"publisher","key":"e_1_2_5_20_1","DOI":"10.1002\/tox.22535"},{"doi-asserted-by":"publisher","key":"e_1_2_5_21_1","DOI":"10.1007\/s10847-008-9450-4"},{"doi-asserted-by":"publisher","key":"e_1_2_5_22_1","DOI":"10.2147\/IJN.S99911"},{"doi-asserted-by":"publisher","key":"e_1_2_5_23_1","DOI":"10.1016\/j.fct.2009.09.002"},{"doi-asserted-by":"publisher","key":"e_1_2_5_24_1","DOI":"10.1016\/j.addr.2007.07.004"},{"issue":"5","key":"e_1_2_5_25_1","first-page":"357","article-title":"Hairless guinea pig skin: anatomical basis for studies of cutaneous biology","volume":"10","author":"Sueki H","year":"2000","journal-title":"Eur J Dermatol"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.13046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13046","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T19:32:51Z","timestamp":1692646371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,27]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/jocd.13046"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13046","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2019,6,27]]},"assertion":[{"value":"2019-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}