{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:38:06Z","timestamp":1788982686525,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ablative CO2 fractional laser (AFL) is a common cosmetic procedure to improve skin laxity. However, due to prolonged downtime and the risk of postinflammatory hyperpigmentation, laser\u2010assisted delivery of active ingredients as post\u2013laser treatment has gained interest in past years. Among various active ingredients, human umbilical cord blood\u2013derived mesenchymal stem cells (hUCBMSCs) can be a promising agent promoting skin regeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We evaluated the efficacy and safety of a human cord blood cell\u2013conditioned media containing serum and cream on patients who underwent AFL treatment. A randomized, investigator\u2010blinded, prospective, split\u2010face comparison study was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010three patients who underwent AFL on both cheeks applied a human umbilical cord blood\u2013derived mesenchymal stem cell (hUCBMSC)\u2010conditioned media containing cream with or without stem cell containing serum application. As a primary outcome measure, we evaluated the total area of microcrusts and post\u2010treatment erythema using digital photographs. Additionally, skin biophysical parameters (corneometer, TEWL) and global improvement scores for skin texture were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The area of total microcrusts was reduced in the study group which applied both serum and cream. The global improvement score of the post\u2010treatment erythema was significantly reduced. Investigator\u2010assessed global improvement scores were higher in the combination treatment group. Additionally, there was no adverse event, which was associated with the use of either hUCBMSCs containing serum or cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The application of human cord blood cell containing serum and cream resulted in accelerated wound healing and reduced post\u2010treatment erythema, which effectively reduced recovery time after ablative laser treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13063","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T10:18:56Z","timestamp":1563790736000},"page":"651-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The effect of human umbilical cord blood\u2013derived mesenchymal stem cell media containing serum on recovery after laser treatment: A double\u2010blinded, randomized, split\u2010face controlled study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-5941","authenticated-orcid":false,"given":"Jihee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine Seoul Korea"},{"name":"Scar Laser and Plastic Surgery Center Yonsei Cancer Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soomin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young In","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine Seoul Korea"},{"name":"Scar Laser and Plastic Surgery Center Yonsei Cancer Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1739-5956","authenticated-orcid":false,"given":"Ju Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine Seoul Korea"},{"name":"Scar Laser and Plastic Surgery Center Yonsei Cancer Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"issue":"4","key":"e_1_2_6_2_1","first-page":"352","article-title":"Multi\u2010center clinical study and review of fractional ablative CO2 laser resurfacing for the treatment of rhytides, photoaging, scars and striae","volume":"10","author":"Alexiades\u2010Armenakas M","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20048"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20755"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12285"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2395"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368910X520065"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12512"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0342"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X686841"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2401"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01377.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12691"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2168-z"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2014.EDIT18.2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.05.018"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2581"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2013.10.003"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7412304"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13063","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:09:23Z","timestamp":1694131763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/jocd.13063"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13063","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,22]]},"assertion":[{"value":"2019-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}