{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T21:26:03Z","timestamp":1786224363179,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","award":["04-2013-005"],"award-info":[{"award-number":["04-2013-005"]}],"id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>We previously reported the efficacy of 0.1% 4\u2010n\u2010butylresorcinol (4nBR) cream in the treatment melasma and synergistic effect of 4nBR and resveratrol (RSV) to inhibit melanogenesis in vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate efficacy and safety of a cream which contains liposome\u2010encapsulated 4nBR and RSV in the treatment of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>A total of 21 female patients with melasma were treated with the cream for 4\u00a0weeks. At baseline, week 2, and week 4, melanin index (MI) of the lesional and preauricular nonlesional skin was measured and two blinded, independent dermatologists assessed the overall severity by 5\u2010point scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lesional MI was significantly decreased at weeks 2 and 4 compared with the baseline while no significant change in the nonlesional MI was observed throughout the study. The mean investigator's global assessment score was also significantly improved at weeks 2 and 4. In patient's self\u2010assessment, 8 (38.1%) and 11 (52.3%) patients answered moderate to significant improvement in their melasma at weeks 2 and 4, respectively. No serious adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The cream containing liposome\u2010encapsulated 4nBR and RSV was shown to be effective and safe for the treatment of melasma with its effect appearing as early as 2\u00a0weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13080","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T10:53:43Z","timestamp":1564138423000},"page":"891-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy of liposome\u2010encapsulated 4\u2010n\u2010butylresorcinol and resveratrol cream in the treatment of melasma"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7295-5725","authenticated-orcid":false,"given":"Soon\u2010Hyo","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine, Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4271-033X","authenticated-orcid":false,"given":"Ji Hoon","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine, Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1166-0189","authenticated-orcid":false,"given":"Jung\u2010Won","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine, Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1588-3307","authenticated-orcid":false,"given":"Kyoung\u2010Chan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine, Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3944-7777","authenticated-orcid":false,"given":"Chang\u2010Hun","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine, Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-2490","authenticated-orcid":false,"given":"Jung\u2010Im","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine, Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13844"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00334.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2005.40202.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.06.029"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12051"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.1.21"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00787.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040956"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12458"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1556-0"},{"issue":"6","key":"e_1_2_7_12_1","first-page":"542","article-title":"Hypopigmentary effects of 4\u2010n\u2010butylresorcinol and resveratrol in combination","volume":"67","author":"Kim SY","year":"2012","journal-title":"Pharmazie"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.2216"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03100.x"},{"issue":"12","key":"e_1_2_7_15_1","first-page":"1363","article-title":"Liposomes from soya phospholipids as percutaneous drug carriers. 1st communication: qualitative in vivo investigations with antibody\u2010loaded liposomes","volume":"40","author":"Artmann C","year":"1990","journal-title":"Arzneimittelforschung"},{"issue":"5","key":"e_1_2_7_16_1","first-page":"448","article-title":"Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children","volume":"17","author":"Kanehara S","year":"2007","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700840"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1476-5586(03)80019-2"},{"issue":"5","key":"e_1_2_7_19_1","first-page":"635","article-title":"Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells","volume":"31","author":"Chen ML","year":"2006","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.07.014"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2017.05.026"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069943"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04464.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01402.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2000.006004230.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12038"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2011.00639.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.13080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:59:58Z","timestamp":1693879198000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,26]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/jocd.13080"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13080","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,26]]},"assertion":[{"value":"2019-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}