{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:59:12Z","timestamp":1788454752541,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Excimer laser therapy of vitiligo generally takes months to years to achieve excellent outcomes. Platelet\u2010rich plasma is an autologous preparation with a focus on various growth factors that can help with vitiligo repigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the additive effect of PRP in the therapy of vitiligo on the results of the excimer laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A comparative study included 52 patients (8 males and 44 females) in two groups with stable (no new lesion for 6\u00a0months), nonsegmental and symmetrical vitiligo. Group I (26 patients): The patient was treated by intradermal PRP injection and the excimer laser, while group II (26 patients) was treated with the excimer laser only. The PRP injection was repeated every 3\u00a0weeks for 4\u00a0months and excimer laser two times a week and for 16\u00a0weeks till complete response. VAS for patient's satisfaction assessment, safety assessment for complications, and follow\u2010up for 3\u00a0months was done. Clinical (repigmentation response) and histopathological assessment was done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a higher statistically significant treatment response in group I compared with group II. In addition, a statistically significant correlation between the treatment response and the lesion site in group I (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.000). A significant difference in VAS between both groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.000). Few the side effects were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of PRP and excimer laser phototherapy is an efficient vitiligo treatment as PRP increases the excimer laser impact and also improves the result.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13103","type":"journal-article","created":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T14:57:40Z","timestamp":1569077860000},"page":"869-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Evaluation of combined excimer laser and platelet\u2010rich plasma for the treatment of nonsegmental vitiligo: A prospective comparative study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2600-4021","authenticated-orcid":false,"given":"Fathia M.","family":"Khattab","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of 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