{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:19:50Z","timestamp":1757456390570,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple sclerosis (MS) is a chronic and inflammatory autoimmune disease. These patients may manifest severe inflammatory cutaneous reactions after using interferon\u00a0beta\u20101b. This article describes a 55\u2010year\u2010old man with severe injection site reactions after 10\u00a0years administration of interferon beta\u20101b. The biopsy specimens revealed skin and subcutaneous tissue necrosis. Histologic evaluation revealed nonspecific inflammatory reactions with no evidence of vasculitis or granulomatous reactions. Based on clinical and pathological findings, the diagnosis of skin and soft tissue necrosis due to interferon injection was given. The injection of interferon beta\u20101b in the affected areas was stopped, and the patient's clinical condition improved by wound care. This report is aimed to increase awareness about severe adverse skin reactions, which may infrequently occur with subcutaneous interferon beta\u20101b injection after several years. Early diagnosis of this reaction can help to prevent associated complications.<\/jats:p>","DOI":"10.1111\/jocd.13104","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T10:58:51Z","timestamp":1566471531000},"page":"951-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cutaneous necrotic lesion: A wonderful delay adverse effect of interferon beta\u20101b injection for multiple sclerosis treatment"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4691-2606","authenticated-orcid":false,"given":"Nikoo","family":"Mozafari","sequence":"first","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-924X","authenticated-orcid":false,"given":"Ali","family":"Saffaei","sequence":"additional","affiliation":[{"name":"Student Research Committee, Department of Clinical Pharmacy, School of Pharmacy Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5778-3419","authenticated-orcid":false,"given":"Mohammad","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-8325","authenticated-orcid":false,"given":"Minoosh","family":"Shabani","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center Shahid Beheshti 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