{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:24Z","timestamp":1787771964400,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T00:00:00Z","timestamp":1566604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mesotherapy is a procedure that involves the injection of active substances into the dermis and subcutaneous tissue in order to treat several local medical and cosmetic conditions. Despite being considered as a relatively safe method, a series of adverse reactions can occur due to its wide application and lack of standardization processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this paper is to summarize all the mesotherapy\u2010related complications published so far, and to provide an insight into their management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient\/Methods<\/jats:title><jats:p>Articles derived from the databases, PubMed, EMBASE, and SCOPUS, and published between 1992 and 2018, were analyzed for this review. The study was conducted according to the PRISMA guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this literature, there is a number of case series and isolated case reports describing various side effects of different severities. The therapeutic management of these complications is\u2014in most cases\u2014individualized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Larger systematic studies are needed in order to adequately evaluate the safety profile of mesotherapy, and in order to determine standardized therapy parameters, so as to minimize the risk of potential adverse reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13115","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T08:10:41Z","timestamp":1566634241000},"page":"1601-1605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Mesotherapy: Safety profile and management of complications"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4116-6344","authenticated-orcid":false,"given":"Kerasia\u2010Maria","family":"Plachouri","sequence":"first","affiliation":[{"name":"Dermatology Department University of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/THC-174624"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12545"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710355105"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2018.1533549"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14690"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v30i3.264"},{"issue":"44","key":"e_1_2_7_8_1","first-page":"1127","article-title":"Outbreak of mesotherapy\u2010associated skin reactions\u2013district of Columbia area, january\u2010february 2005","volume":"54","author":"Centers for Disease Control and Prevention (CDC)","year":"2005","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2011.03.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324766"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2009.08.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2011.02.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.7883\/yoken.63.143","article-title":"Outbreak of mesotherapy\u2010associated cutaneous infections caused by Mycobacterium chelonae in Colombia","volume":"63","author":"Correa NE","year":"2010","journal-title":"Jpn J Infect Dis"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/606050"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03461.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550152572967"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03487.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1502.081125"},{"key":"e_1_2_7_19_1","first-page":"728","article-title":"Mycobacterial bovis BCG cutaneous infections following mesotherapy: 2 cases","volume":"129","author":"Marco\u2010Bonnet J","year":"2002","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05649.x"},{"key":"e_1_2_7_21_1","first-page":"1","article-title":"Infecci\u00f3n cut\u00e1nea por Micobacterias y Nocardia asociada a mesoterpia","volume":"20","author":"Gonz\u00e1lez F","year":"2004","journal-title":"Vitae"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0271"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1303167"},{"key":"e_1_2_7_24_1","unstructured":"Alfaro\u2010RubioA Martorell\u2010CalatayudA PelufoC TerradezL Hueso\u2010GabrielL GarciaMelgaresML.Mesotherapy granulomas with L\u2010carnitine. 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