{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:47:12Z","timestamp":1770335232640,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris (AV) is an inflammatory skin disorder that may be associated with metabolic disorders. The relation between lipid profile in acne is not widely investigated. Chitinase\u20103\u2010like protein 1 (YKL\u201040) has been found to be implicated in different inflammatory conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed at investigating the role YKL\u201040 in acne pathogenesis and associated dyslipidemia in acne patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This study included 50 acne vulgaris patients and 30 matched control subjects. Serum YKL\u201040 in addition to lipid profile were assessed in all studied subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum YKL\u201040 level was significantly elevated in acne patients than healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). We also found a significant positive correlations between serum YKL\u201040, serum TGs, TC, and LDL\u2010C (<jats:italic>P<\/jats:italic> value: .022, .001, .017 respectively) while, a significant negative correlation between serum YKL\u201040 and HDL\u2010c (<jats:italic>P<\/jats:italic> value: .036) was detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study results suggest that YKL\u201040 might have a role in AV pathogenesis. In addition, it could provide a new potential link between inflammation and dyslipidemia observed in acne patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13124","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T12:30:31Z","timestamp":1567773031000},"page":"1219-1223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris"],"prefix":"10.1111","volume":"19","author":[{"given":"Adel","family":"Ebrahim","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3877-5787","authenticated-orcid":false,"given":"Amany Ibrahim","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Benha 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