{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:31:40Z","timestamp":1784943100449,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>VYC\u201012, a hyaluronic acid injectable gel, is designed to treat fine lines and provides improvements in other skin quality attributes. A prospective study demonstrated the safety and effectiveness of VYC\u201012 for the improvement of fine lines as measured by changes in skin texture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate patient\u2010reported outcomes in subjects treated intradermally with VYC\u201012 in the cheeks, forehead, and neck (optional) in the prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects received an initial treatment of VYC\u201012 (N\u00a0=\u00a0131), with a touch\u2010up treatment, if deemed necessary, offered 30\u00a0days later, and optional repeat treatment 9\u00a0months after initial or touch\u2010up treatment. Subjects completed the FACE\u2010Q Satisfaction With Skin scale and assessed willingness to recommend treatment to a friend at baseline, months 1, 4, 6, and 9, and month 1 after repeat treatment. Subjects also evaluated their return to normal daily social activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Satisfaction with skin improved from baseline in 90.8% of subjects at month 1, 88.4% at month 4, 83.6% at month 6, 76.4% at month 9, and 91.9% at month 1 after repeat treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, all time points). At least 94% of subjects returned to normal daily social activities one day after treatment (initial, touch\u2010up, or repeat). More than 80% of subjects said they would recommend treatment to a friend at all time points through month 9 (97% at month 1 after repeat treatment).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with VYC\u201012 significantly improved satisfaction with skin in the majority of subjects, with most subjects returning to normal activities 1\u00a0day after treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13129","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T08:54:05Z","timestamp":1571302445000},"page":"1065-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Improvements in satisfaction with skin after treatment of facial fine lines with VYC\u201012 injectable gel: Patient\u2010reported outcomes from a prospective study"],"prefix":"10.1111","volume":"19","author":[{"given":"Patricia","family":"Ogilvie","sequence":"first","affiliation":[{"name":"SkinConcept Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marva","family":"Safa","sequence":"additional","affiliation":[{"name":"La Jouvence Neuch\u00e2tel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonquille","family":"Chantrey","sequence":"additional","affiliation":[{"name":"\u00d8NE aesthetic studi\u00f8 Cheshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Leys","sequence":"additional","affiliation":[{"name":"Medical Skincare Sint\u2010Truiden Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Cavallini","sequence":"additional","affiliation":[{"name":"Unit of Plastic Surgery CDI Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Niforos","sequence":"additional","affiliation":[{"name":"La Jouvence Neuch\u00e2tel Switzerland"},{"name":"Centre Chirurgical Niforos Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Hopfinger","sequence":"additional","affiliation":[{"name":"Allergan plc Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Marx","sequence":"additional","affiliation":[{"name":"Allergan plc Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.09.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.01616"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0027078"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32106.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000847"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000852"},{"key":"e_1_2_6_8_1","first-page":"990","article-title":"Stabilized hyaluronic acid\u2010based gel of non\u2010animal origin for skin rejuvenation: face, hand, and decolletage","volume":"12","author":"Streker M","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/318586"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.09.015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502012001000012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12866"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2005.05.012"},{"key":"e_1_2_6_14_1","first-page":"1","article-title":"Patients' self\u2010esteem before and after chemical peeling procedure","author":"Kouris A","year":"2017","journal-title":"J Cosmet Laser Ther"},{"key":"e_1_2_6_15_1","first-page":"62","article-title":"Assessing improvement of facial appearance and quality of life after minimally\u2010invasive cosmetic dermatology procedures using the FACE\u2010Q scales","volume":"15","author":"Hibler BP","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-012-9992-0"},{"key":"e_1_2_6_17_1","first-page":"48","article-title":"A randomized study to assess the efficacy of skin rejuvenation therapy in combination with neurotoxin and full facial filler treatments","volume":"17","author":"Dayan SH","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001127"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2012.00608.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001823"},{"key":"e_1_2_6_21_1","unstructured":"Juvederm Volite B [direction for use]. 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