{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:49:26Z","timestamp":1789555766460,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Botulinum toxin type A injection is a common aesthetic treatment that can be used alone or in combination to rejuvenate the entire face and neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the safety and efficacy of a full\u2010face approach with botulinum toxin type A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center, retrospective review of data from 189 patients receiving full\u2010face and neck treatment with onabotulinumtoxinA in the following areas: glabellar lines, crow's feet lines, forehead lines, bunny lines, sagging nasal tip, gummy smile, marionette lines, mentalis, masseter, and lateral\/anterior platysma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 56.6\u00a0\u00b1\u00a09.2\u00a0years, and 94.7% were women (n\u00a0=\u00a0179). Patients received a total of 394 full\u2010face treatments (mean: 2.1 per person; range 1\u20107). The mean quantity of onabotulinumtoxinA injected was 113.8\u00a0\u00b1\u00a017.6 units per treatment (range: 50\u2010180 units). The most frequently injected areas were the glabella\/crow's feet\/forehead (n\u00a0=\u00a0383; 97.2%), platysma (n\u00a0=\u00a0378; 95.9%), bunny lines (n\u00a0=\u00a0283; 71.8%), and chin (n\u00a0=\u00a0120; 30.5%). Six patients (3.2%) experienced complications: five cases of unwanted diffusion from the mentalis into the depressor labii inferioris and one case of right eyelid ptosis after injection in the upper third. All were minor and none appeared to be related to overall dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Full\u2010face and neck treatment with onabotulinumtoxinA can be performed without substantial safety concerns, often leading to excellent results. This approach may become increasingly prevalent in the coming years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13130","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T09:42:31Z","timestamp":1567676551000},"page":"809-816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Full\u2010face treatment with onabotulinumtoxinA: Results from a single\u2010center study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3635-5391","authenticated-orcid":false,"given":"Roberta","family":"D'Emilio","sequence":"first","affiliation":[{"name":"Villa Salaria Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-2382","authenticated-orcid":false,"given":"Giuseppe","family":"Rosati","sequence":"additional","affiliation":[{"name":"Villa Salaria Rome 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