{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:34:22Z","timestamp":1789094062430,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>NB\u2010UVB phototherapy is still an effective treatment in vitiligo but requires more than 1\u00a0year for its completion. Topical 5\u2010flurouracil could improve the proliferation and migration of melanocytes. Laser\u2010assisted dermabrasion results in stimulation of the inactive melanocytes present at the outer root sheath of the lower portion of the hair follicle, which migrates upward until they reach the surface of the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of Er:YAG laser skin ablation followed by topical 5\u2010flurouracil on the outcome of NB\u2010UVB phototherapy as a short term technique in resistant and stable vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current study included 40 patients suffering from bilateral stable vitiligo resistant to NB\u2010UVB. For each patient, one side of the body subjected to 4\u00a0months NB\u2010UVB sessions (control side). While the other side of the body subjected to one session of Er:YAG laser ablation combined with topical 5% 5\u2010flurouracil application under occlusion followed by NB\u2010UVB sessions for 4\u00a0months after complete re\u2010epithelization. Outcomes were evaluated objectively based on standard digital photographs, histopathological examination, patient satisfaction, and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a statistically significant improvement in the repigmentation in laser side compared with control side. Histopathological examination revealed expression of prominent melanin pigmentation, with marked expression for Melan\u2010A in laser side, whereas these findings were negative in control side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Er:YAG laser ablation, followed by 5FU application before NB\u2010UVB phototherapy for vitiligo, is a safe and tolerable technique that improves the outcome of short\u2010term NB\u2010UVB therapy and is expected to increase patient compliance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13134","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T07:25:38Z","timestamp":1569914738000},"page":"122-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Study the effect of erbium:YAG laser plus topical 5\u2010flurouracil in stable vitiligo resistant to NB\u2010UVB phototherapy"],"prefix":"10.1111","volume":"19","author":[{"given":"Noha Nabil","family":"Doghaim","sequence":"first","affiliation":[{"name":"Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania Ahmed","family":"El\u2010Tatawy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayada A.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dareen Abdelaziz Mohammed","family":"Ali","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-0927","authenticated-orcid":false,"given":"Yasmina Ahmed","family":"El Attar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"947","volume-title":"Textbook of Dermatology","author":"Ortonne JP","year":"2003"},{"key":"e_1_2_7_3_1","first-page":"238","volume-title":"Practice of Dermatology","author":"Behl PN","year":"2003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00355.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01936.x"},{"key":"e_1_2_7_6_1","first-page":"537","article-title":"Standard guidelines of care for vitiligo surgery","volume":"74","author":"Paesad D","year":"2008","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102030-00006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916930108994127"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2008.00528.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890480045006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.09.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155598433485"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.061598"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00222.x"},{"issue":"6","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2340\/0001555566474478","article-title":"Differential effects of 5\u2010fluorouracil on human skin melanocytes and malignant melanoma cells in vitro","volume":"66","author":"Tsuji T","year":"1986","journal-title":"Acta Dermato\u2010Venereologica"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00313.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2008.00385.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2011.579084"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03226.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10564.x"},{"key":"e_1_2_7_21_1","first-page":"4","article-title":"The effect of ER:YAG plus 5-fluorouracil on the outcome of punch grafting in nonsegmental vitiligo: a left\u2013right comparative study","volume":"36","author":"Anbar TS","year":"2016","journal-title":"EJDV"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/852497"},{"issue":"1","key":"e_1_2_7_23_1","first-page":"95","article-title":"The treatment of ypopigmentation after skin resurfacing","volume":"30","author":"Fulton JE","year":"2004","journal-title":"Dermatol Surg"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06779.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T08:54:36Z","timestamp":1693817676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/jocd.13134"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13134","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2017-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}