{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:08:04Z","timestamp":1790820484596,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"King Edward Medical University","award":["Grant no:3746\/REG\/KEMU\/2016 dated 29.3.2016"],"award-info":[{"award-number":["Grant no:3746\/REG\/KEMU\/2016 dated 29.3.2016"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since antiquity, humans have been trying to devise remedies to cure androgenetic alopecia (AGA). These efforts include use of oral and topical concoctions and hair transplant strategies.\u00a0As AGA affects people of all colors and creed, there has been a continuous effort to find a magic bullet against AGA.\u00a0Unfortunately, to date, all the strategies to negate AGA effects have limitations and thus require new treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of use of stromal vascular fraction (SVF) in androgenetic alopecia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Stromal vascular fraction was obtained by enzymatic digestion of autologous adipose tissue. The patients were divided into two groups, that is, platelet\u2010rich plasma (PRP) group and SVF\u2010PRP group. In PRP group, only PRP was injected, while in SVF\u2010PRP group a mixture of PRP and SVF was injected in affected scalp areas. After two sessions (4\u00a0weeks apart), the patients in both groups were assessed and analyzed using various parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean hair density in PRP group was increased from 52.44\u00a0hair\/cm<jats:sup>2<\/jats:sup> to 63.72\u00a0hair\/cm<jats:sup>2<\/jats:sup> (21.51% increase); while in SVF\u2010PRP group, it was 37.66\u00a0hair\/cm<jats:sup>2<\/jats:sup> before treatment and 57.11\u00a0hair\/cm<jats:sup>2<\/jats:sup> after SVF\u2010PRP therapy (51.64% increase). Percentage reduction in pull test was more significant in SVF\u2010PRP group (80.78\u00a0\u00b1\u00a05.84) as compared to PRP group (34.01\u00a0\u00b1\u00a022.44). The physician and patient assessment scores also indicated a significant improvement in SVF\u2010PRP group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A combined SVF\u2010PRP therapy reversed effects of AGA more efficiently as compared to PRP therapy alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13149","type":"journal-article","created":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T10:18:50Z","timestamp":1569061130000},"page":"1078-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Stromal vascular fraction\u2010enriched platelet\u2010rich plasma therapy reverses the effects of androgenetic alopecia"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-0961","authenticated-orcid":false,"given":"Ghazala","family":"Butt","sequence":"first","affiliation":[{"name":"Department of Dermatology King Edward Medical University\/Mayo Hospital Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ijaz","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Edward Medical University\/Mayo Hospital Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fridoon Jawad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences King Edward Medical University Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-4817","authenticated-orcid":false,"given":"Mahmood S.","family":"Choudhery","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Regenerative Medicine Laboratory Department of Biomedical Sciences King Edward Medical University Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.77510"},{"issue":"6","key":"e_1_2_7_3_1","first-page":"1","article-title":"Promising therapies for treating and\/or preventing androgenic alopecia","volume":"17","author":"McElwee KJ","year":"2012","journal-title":"Skin therapy lett"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2014.316"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjy029"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.138352"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000239560.29172.33"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.150743"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477671"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.019"},{"key":"e_1_2_7_11_1","unstructured":"\u201cFemale pattern baldness\". 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