{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:10:39Z","timestamp":1791465039965,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Microneedling is a valuable tool that can be used in transdermal drug delivery in vitiligo patients to improve drug permeability and efficacy with minor side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study is to assess the effectiveness of using microneedling prior to application of topical 5\u2010FU in treatment of localized vitiligo and to compare its results with microneedling alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010seven patients with localized stable vitiligo are chosen. Two patches are determined in every patient: patch A treated with needling alone and patch B treated with needling followed by topical application of 5\u2010fluorouracil once every 2\u00a0weeks for three months. Repigmentation was accessed by grades ranging from G0; no response to G4; &gt;75% repigmentation. Side effects were reported in every visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Microneedling followed by topical application of 5\u2010fluorouracil showed better response than needling alone with minimal side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combining microneedling with topical drug application yields better results in treating localized vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13152","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T15:29:10Z","timestamp":1568647750000},"page":"1473-1478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Evaluation of the additional effect of topical 5\u2010fluorouracil to needling in the treatment of localized vitiligo"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9406-1431","authenticated-orcid":false,"given":"Enayat Mohamed","family":"Attwa","sequence":"first","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-6908","authenticated-orcid":false,"given":"Shrook A.","family":"Khashaba","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal Anwar","family":"Ezzat","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2011.00583.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.09.024"},{"key":"e_1_2_6_4_1","first-page":"44","article-title":"Microneedling and its applications in dermatology","volume":"4","author":"Majid I","year":"2014","journal-title":"Prime"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03291.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2012.11.001"},{"issue":"2","key":"e_1_2_6_7_1","first-page":"125","article-title":"Control of development by steady ionic currents","volume":"40","author":"Jaffe LF","year":"1981","journal-title":"Fed Proc"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710355105"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/JMEMS.2003.820293"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05921.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-011-9288-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3054-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2014.1003241"},{"key":"e_1_2_6_14_1","first-page":"177","article-title":"Efficacy of narrowband ultraviolet B phototherapy with needling in patients of vitiligo","volume":"25","author":"Batool S","year":"2015","journal-title":"JPAD"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","unstructured":"FernandesD.The holistic scarless rejuvenation of the face mini invasive face and body lifts\u2010closed suture lifts or barbed thread lifts: Nikolay Serdev. 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