{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:09:28Z","timestamp":1789607368283,"version":"build-2803163510"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma treatments have varying success and are associated with some complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the effectiveness of platelet\u2010rich plasma (PRP) treatment for melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten female patients with bilateral mixed\u2010type melasma were enrolled in our randomized, split\u2010face, single\u2010blinded prospective trial. Over 4 treatment sessions that each took place every 2\u00a0weeks, PRP was injected intradermally on one side of the face (PRP condition) and normal saline on the other (control condition). PRP was prepared by using the YCELLBIO Kit<jats:sup>\u00ae<\/jats:sup>. Outcomes were evaluated with the modified Melasma Area and Severity Index (mMASI), Mexameter<jats:sup>\u00ae<\/jats:sup>, and Antera<jats:sup>\u00ae<\/jats:sup> 3D. Patient satisfaction was also assessed at baseline, at 2, 4, and 6\u00a0weeks, and 1\u00a0month after treatment completion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>mMASI score and Antera<jats:sup>\u00ae<\/jats:sup> 3D\u2010assessed melanin levels show significant improvement in the PRP condition than control condition between baseline and week 6, while patient satisfaction significantly increased over time. However, Mexameter<jats:sup>\u00ae<\/jats:sup>\u2010assessed erythema and melanin indices did not significantly differ between the control and PRP conditions, though there was a trend toward reduced pigmentation in the latter. Finally, side effects of treatment were mild and resolved spontaneously within a few days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first randomized, placebo\u2010controlled trial study using PRP for treatment of melasma. PRP injection significantly improved melasma within 6\u00a0weeks of treatment in terms of mMASI scores, patient satisfaction, and Antera<jats:sup>\u00ae<\/jats:sup>\u2010assessed melanin levels. Hence, intradermal PRP injection could be used as an alternative or adjuvant therapy for melasma. However, additional trials are needed for more rigorous evaluation of its long\u2010term efficacy and safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13157","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:16:35Z","timestamp":1569906995000},"page":"1321-1327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Platelet\u2010rich plasma treatment for melasma: A pilot study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5107-8153","authenticated-orcid":false,"given":"Punyaphat","family":"Sirithanabadeekul","sequence":"first","affiliation":[{"name":"Department of Dermatology Chulabhorn International College of Medicine Thammasat University Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arada","family":"Dannarongchai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chulabhorn International College of Medicine Thammasat University Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-7090","authenticated-orcid":false,"given":"Atchima","family":"Suwanchinda","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of AntiAging and Regenerative Medicine Mae Fah Luang University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.142484"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2011.630088"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0038-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.3.401"},{"issue":"2","key":"e_1_2_7_6_1","first-page":"1","article-title":"Response to intradermal autologous platelet rich plasma injection in refractory dermal melasma: report of two cases","volume":"18","author":"Yew CH","year":"2015","journal-title":"JUMMEC"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2014.10.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02280.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.13157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T12:34:47Z","timestamp":1693744487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/jocd.13157"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13157","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,30]]},"assertion":[{"value":"2019-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}