{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:21:11Z","timestamp":1787498471042,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Biodue S.p.A"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melasma\u2014a localized chronic acquired hypermelanosis\u2014is common in adult women and it is difficult to treat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We designed a pilot, uncontrolled open\u2010label study to evaluate the appearance of epidermal melasma after 6\u00a0months of twice\u2010daily application of a nonprescription proprietary gel formulation containing glabridin, andrographolide, and apolactoferrin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>A total of 40 Caucasian women with epidermal melasma (Fitzpatrick skin types II\u2010VI) were enrolled. The study endpoints included standardized clinical photography, determination of Melasma Area and Severity Index (MASI) scores, spectrocolorimeter X\u2010Rite analysis, in vivo reflectance confocal microscopy (RCM), and self\u2010assessment of cosmetic acceptability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All endpoints showed a statistically significant improvement of epidermal melasma from baseline to the end of the study. There were no dropouts and cosmetic acceptability was rated as excellent by all of the study patients. The only observed adverse event was a mild, transient xerosis (n\u00a0=\u00a03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Favorable outcomes, as demonstrated by investigator and instrumental assessments, were demonstrated using a proprietary gel for the treatment of epidermal melasma in adult women. Our results need to be confirmed in independent placebo\u2010controlled studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.13161","type":"journal-article","created":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T10:57:28Z","timestamp":1569063448000},"page":"1395-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A new proprietary gel containing glabridin, andrographolide, and apolactoferrin improves the appearance of epidermal melasma in adult women: A 6\u2010month pilot, uncontrolled open\u2010label study"],"prefix":"10.1111","volume":"19","author":[{"given":"Mariateresa","family":"Cantelli","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery Section of Dermatology University of Naples Federico II Naples 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